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Drug Name | ONC201 |
Trade Name | |
Synonyms | TIC-10|TIC10|dordaviprone |
Drug Descriptions |
ONC201 (TIC-10) binds to the G-protein coupled receptor, DRD2, leading to inactivation of AKT and ERK, which relocates Foxo3a to the nucleus and then leads to tumor cell apoptosis mediated by (TNF)-related apoptosis-inducing ligand (TRAIL) signaling (PMID: 23390247) and targets the mitochondrial protease, ClpP (PMID: 31021596, PMID: 31702782, PMID: 31456142). |
DrugClasses | Akt Inhibitor (Pan) 21 ERK Inhibitor (pan) 21 |
CAS Registry Number | 1616632-77-9 |
NCIT ID | C113792 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + ONC201 | Atezolizumab ONC201 | 0 | 1 |
Bevacizumab + ONC201 | Bevacizumab ONC201 | 0 | 0 |
Dexamethasone + Ixazomib + ONC201 | Dexamethasone Ixazomib ONC201 | 0 | 1 |
Docetaxel + ONC201 | Docetaxel ONC201 | 0 | 0 |
GDC-0084 + ONC201 | GDC-0084 ONC201 | 0 | 1 |
Ibrutinib + ONC201 | Ibrutinib ONC201 | 0 | 0 |
Navitoclax + ONC201 | Navitoclax ONC201 | 1 | 0 |
Nivolumab + ONC201 | Nivolumab ONC201 | 0 | 1 |
ONC201 | ONC201 | 0 | 24 |
ONC201 + Paclitaxel | ONC201 Paclitaxel | 0 | 1 |
ONC201 + Panobinostat | ONC201 Panobinostat | 0 | 1 |
ONC201 + Venetoclax | ONC201 Venetoclax | 0 | 0 |