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| Drug Name | ONC201 |
| Trade Name | |
| Synonyms | TIC-10|TIC10|dordaviprone |
| Drug Descriptions |
ONC201 (TIC-10) binds to the G-protein coupled receptor, DRD2, leading to inactivation of AKT and ERK, which relocates Foxo3a to the nucleus and then leads to tumor cell apoptosis mediated by (TNF)-related apoptosis-inducing ligand (TRAIL) signaling (PMID: 23390247) and targets the mitochondrial protease, ClpP (PMID: 31021596, PMID: 31702782, PMID: 31456142). |
| DrugClasses | Akt Inhibitor (Pan) 21 ERK Inhibitor (pan) 21 |
| CAS Registry Number | 1616632-77-9 |
| NCIT ID | C113792 |
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