Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name GDC-0084
Trade Name
Synonyms GDC0084|Paxalisib
Drug Descriptions

Paxalisib (GDC-0084) is a dual pan-PI3K and mTOR inhibitor, which prevents cell proliferation and potentially inhibits tumor growth (PMID: 22619466, PMID: 32269051, PMID: 31937616).

DrugClasses mTOR Inhibitor 51 PI3K Inhibitor (Pan) 42
CAS Registry Number 1382979-44-3
NCIT ID C116877

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
GDC-0084 GDC-0084 1 6
GDC-0084 + Irinotecan + Temozolomide GDC-0084 Irinotecan Temozolomide 0 1
GDC-0084 + Metformin GDC-0084 Metformin 0 1
GDC-0084 + ONC201 GDC-0084 ONC201 0 1
GDC-0084 + Trastuzumab GDC-0084 Trastuzumab 0 1


Additional content available in CKB BOOST