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Drug Detail
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| Drug Name | Pacritinib |
| Trade Name | Vonjo |
| Synonyms | SB1518|SB-1518|SB 1518 |
| Drug Descriptions |
Vonjo (pacritinib) is an inhibitor of JAK2 and FLT3, with activity against JAK2 V617F and FLT3 ITD, which potentially increases tumor cell apoptosis, induces cell cycle arrest, and decreases tumor growth (PMID: 22829080, PMID: 21691275). Vonjo (pacritinib) is FDA approved for use in patients with primary or secondary myelofibrosis (FDA.gov). |
| DrugClasses | FLT3 Inhibitor 69 JAK2 Inhibitor - ATP competitive 15 |
| CAS Registry Number | 937272-79-2 |
| NCIT ID | C78837 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Acalabrutinib + Pacritinib | Acalabrutinib Pacritinib | 0 | 1 |
| Azacitidine + Pacritinib | Azacitidine Pacritinib | 0 | 1 |
| Bemcentinib + Pacritinib | Bemcentinib Pacritinib | 0 | 1 |
| Cytarabine + Daunorubicin + Pacritinib | Cytarabine Daunorubicin Pacritinib | 1 | 1 |
| Cytarabine + Pacritinib | Cytarabine Pacritinib | 0 | 1 |
| Decitabine + Pacritinib | Decitabine Pacritinib | 1 | 3 |
| Erlotinib + Pacritinib | Erlotinib Pacritinib | 0 | 1 |
| Ibrutinib + Pacritinib | Ibrutinib Pacritinib | 0 | 2 |
| Pacritinib | Pacritinib | 19 | 9 |
| Pacritinib + Talazoparib | Pacritinib Talazoparib | 0 | 1 |
| Pacritinib + Zanubrutinib | Pacritinib Zanubrutinib | 0 | 1 |
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