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Drug Name | PEGPH20 |
Trade Name | |
Synonyms | Pegvorhyaluronidase alfa |
Drug Descriptions |
Pegvorhyaluronidase alfa (PEGPH20) is a pegylated version of hyaluronidase, which degrades endogenous hyaluronic acid within tumors, potentially resulting in decreased growth of tumor cells and increased penetration of other therapeutic agents (PMID: 32706635). |
DrugClasses | |
CAS Registry Number | 1620390-06-8 |
NCIT ID | C82659 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + Cisplatin + Gemcitabine + PEGPH20 | Atezolizumab Cisplatin Gemcitabine PEGPH20 | 0 | 1 |
Atezolizumab + PEGPH20 | Atezolizumab PEGPH20 | 0 | 3 |
Cetuximab + PEGPH20 | Cetuximab PEGPH20 | 0 | 1 |
Cisplatin + Gemcitabine + PEGPH20 | Cisplatin Gemcitabine PEGPH20 | 0 | 1 |
Gemcitabine + Nab-paclitaxel + PEGPH20 | Gemcitabine Nab-paclitaxel PEGPH20 | 0 | 1 |
PEGPH20 | PEGPH20 | 0 | 0 |
PEGPH20 + Pembrolizumab | PEGPH20 Pembrolizumab | 0 | 3 |