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Drug Name Siremadlin
Trade Name
Synonyms HDM201|HDM-201|NVP-HDM201
Drug Descriptions

Siremadlin (HDM201) binds to MDM2 and inhibits its interaction with p53, which prevents p53 degradation and potentially leads to restoration of p53 signaling and increased tumor cell death (PMID: 30899200, PMID: 27542305).

DrugClasses MDM2 Inhibitor 23
CAS Registry Number 1448867-41-1
NCIT ID C116325

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Siremadlin + Venetoclax Azacitidine Siremadlin Venetoclax 0 1
IDE196 + Siremadlin IDE196 Siremadlin 0 1
Pazopanib + Siremadlin Pazopanib Siremadlin 0 1
Ribociclib + Siremadlin Ribociclib Siremadlin 0 2
Sabatolimab + Siremadlin Sabatolimab Siremadlin 0 1
Siremadlin Siremadlin 3 3
Siremadlin + Trametinib Siremadlin Trametinib 0 1
Siremadlin + Venetoclax Siremadlin Venetoclax 0 1


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