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| Drug Name | Siremadlin |
| Trade Name | |
| Synonyms | HDM201|HDM-201|NVP-HDM201 |
| Drug Descriptions |
Siremadlin (HDM201) binds to MDM2 and inhibits its interaction with p53, which prevents p53 degradation and potentially leads to restoration of p53 signaling and increased tumor cell death (PMID: 30899200, PMID: 27542305). |
| DrugClasses | MDM2 Inhibitor 23 |
| CAS Registry Number | 1448867-41-1 |
| NCIT ID | C116325 |
| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Azacitidine + Siremadlin + Venetoclax | Azacitidine Siremadlin Venetoclax | 0 | 1 |
| IDE196 + Siremadlin | IDE196 Siremadlin | 0 | 1 |
| Pazopanib + Siremadlin | Pazopanib Siremadlin | 0 | 1 |
| Ribociclib + Siremadlin | Ribociclib Siremadlin | 0 | 1 |
| Sabatolimab + Siremadlin | Sabatolimab Siremadlin | 0 | 1 |
| Siremadlin | Siremadlin | 3 | 3 |
| Siremadlin + Trametinib | Siremadlin Trametinib | 0 | 1 |
| Siremadlin + Venetoclax | Siremadlin Venetoclax | 0 | 1 |