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Drug Name | Siremadlin |
Trade Name | |
Synonyms | HDM201|HDM-201|NVP-HDM201 |
Drug Descriptions |
Siremadlin (HDM201) binds to MDM2 and inhibits its interaction with p53, which prevents p53 degradation and potentially leads to restoration of p53 signaling and increased tumor cell death (PMID: 30899200, PMID: 27542305). |
DrugClasses | MDM2 Inhibitor 23 |
CAS Registry Number | 1448867-41-1 |
NCIT ID | C116325 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Azacitidine + Siremadlin + Venetoclax | Azacitidine Siremadlin Venetoclax | 0 | 1 |
IDE196 + Siremadlin | IDE196 Siremadlin | 0 | 1 |
Pazopanib + Siremadlin | Pazopanib Siremadlin | 0 | 1 |
Ribociclib + Siremadlin | Ribociclib Siremadlin | 0 | 2 |
Sabatolimab + Siremadlin | Sabatolimab Siremadlin | 0 | 1 |
Siremadlin | Siremadlin | 3 | 3 |
Siremadlin + Trametinib | Siremadlin Trametinib | 0 | 1 |
Siremadlin + Venetoclax | Siremadlin Venetoclax | 0 | 1 |