Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name Pazopanib
Trade Name Votrient
Synonyms GW-786034
Drug Descriptions

Votrient (pazopanib) inhibits VEGFR-1, -2 and -3, KIT, and PDGFR, and FGFR1, 2, and 3, leading to decreased tumor angiogenesis and growth (PMID: 17620431, PMID: 23786770). Votrient (pazopanib) is approved for renal cell carcinoma and soft tissue sarcoma (FDA.gov).

DrugClasses FGFR1 Inhibitor 28 FGFR2 Inhibitor 23 FGFR3 Inhibitor 19 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 VEGFR Inhibitor (Pan) 36
CAS Registry Number 444731-52-6
NCIT ID C74547

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abexinostat + Pazopanib Abexinostat Pazopanib 0 1
Alisertib + Pazopanib Alisertib Pazopanib 0 1
Bevacizumab + Pazopanib Bevacizumab Pazopanib 0 1
Carboplatin + Paclitaxel + Pazopanib Carboplatin Paclitaxel Pazopanib 0 0
Carotuximab + Pazopanib Carotuximab Pazopanib 0 3
Cetuximab + Pazopanib Cetuximab Pazopanib 0 1
Crizotinib + Pazopanib Crizotinib Pazopanib 1 1
Crizotinib + Pazopanib + Pemetrexed Disodium Crizotinib Pazopanib Pemetrexed Disodium 0 1
Dabrafenib + Pazopanib Dabrafenib Pazopanib 0 1
Docetaxel + Gemcitabine + Pazopanib Docetaxel Gemcitabine Pazopanib 0 2
Docetaxel + Pazopanib + Pegfilgrastim Docetaxel Pazopanib Pegfilgrastim 0 1
Doxorubicin + Ifosfamide + Pazopanib Doxorubicin Ifosfamide Pazopanib 0 1
Everolimus + Pazopanib Everolimus Pazopanib 0 1
Evofosfamide + Pazopanib Evofosfamide Pazopanib 0 1
Gemcitabine + Pazopanib Gemcitabine Pazopanib 0 4
Irinotecan + Pazopanib + Temozolomide Irinotecan Pazopanib Temozolomide 0 1
Nab-rapamycin + Pazopanib Nab-rapamycin Pazopanib 0 1
Nivolumab + Pazopanib Nivolumab Pazopanib 0 1
Paclitaxel + Pazopanib Paclitaxel Pazopanib 0 3
Panobinostat + Pazopanib Panobinostat Pazopanib 0 1
Pazopanib Pazopanib 14 50
Pazopanib + Pembrolizumab Pazopanib Pembrolizumab 0 0
Pazopanib + Pemetrexed Disodium Pazopanib Pemetrexed Disodium 0 1
Pazopanib + PRT1419 PRT1419 Pazopanib 1 0
Pazopanib + REC-2282 Pazopanib REC-2282 0 1
Pazopanib + Siremadlin Pazopanib Siremadlin 0 1
Pazopanib + Spartalizumab Pazopanib Spartalizumab 0 1
Pazopanib + Sunitinib Pazopanib Sunitinib 0 1
Pazopanib + Temozolomide Pazopanib Temozolomide 0 1
Pazopanib + Topotecan Pazopanib Topotecan 0 5
Pazopanib + Trabectedin Pazopanib Trabectedin 0 0
Pazopanib + Trametinib Pazopanib Trametinib 1 1
Pazopanib + Trebananib Pazopanib Trebananib 0 1
Pazopanib + Vorinostat Pazopanib Vorinostat 4 0


Additional content available in CKB BOOST