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Drug Name | LGH447 |
Trade Name | |
Synonyms | LGB321|PIM447|LGH-447|PIM-447 |
Drug Descriptions |
LGH447 is a pan-PIM protein kinase inhibitor, which leads to cell cycle arrest and growth inhibition in PIM-expressing tumor cells (PMID: 24474669, PMID: 30370255). |
DrugClasses | PIM Inhibitor (Pan) 9 |
CAS Registry Number | 1210608-43-7 |
NCIT ID | C106259 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Alpelisib + LGH447 | Alpelisib LGH447 | 0 | 1 |
Bortezomib + Dexamethasone + LGH447 | Bortezomib Dexamethasone LGH447 | 0 | 0 |
Cytarabine + LGH447 | Cytarabine LGH447 | 0 | 0 |
Dexamethasone + Lenalidomide + LGH447 | Dexamethasone LGH447 Lenalidomide | 0 | 0 |
Dexamethasone + LGH447 | Dexamethasone LGH447 | 0 | 0 |
Dexamethasone + LGH447 + Pomalidomide | Dexamethasone LGH447 Pomalidomide | 0 | 0 |
LGH447 | LGH447 | 1 | 3 |
LGH447 + Ribociclib + Ruxolitinib | LGH447 Ribociclib Ruxolitinib | 2 | 0 |