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Drug Name | SGT-53 |
Trade Name | |
Synonyms | transferrin receptor-targeted liposomal p53 cDNA|Synerlip p53 |
Drug Descriptions |
SGT-53 is a cationic liposomal complex that is linked to an antibody targeting the transferrin receptor (Tff) and contains wild-type Tp53 plasmid, thereby delivering wild-type Tp53 to tumor cells expressing Tff and potentially restoring wild-type Tp53 activity (PMID: 23470564, PMID: 27357628, PMID: 31241175) |
DrugClasses | p53 Gene Therapy 4 |
CAS Registry Number | NA |
NCIT ID | C29474 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Bevacizumab + Irinotecan + SGT-53 + Temozolomide | Bevacizumab Irinotecan SGT-53 Temozolomide | 0 | 1 |
Carboplatin + Pembrolizumab + SGT-53 | Carboplatin Pembrolizumab SGT-53 | 0 | 1 |
Cyclophosphamide + SGT-53 + Topotecan | Cyclophosphamide SGT-53 Topotecan | 0 | 1 |
Docetaxel + SGT-53 | Docetaxel SGT-53 | 0 | 0 |
SGT-53 | SGT-53 | 0 | 2 |