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Drug Detail

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Drug Name Danvatirsen
Trade Name
Synonyms ISIS 481464|ISIS-STAT3rx|AZD9150
Drug Descriptions

Danvatirsen (AZD9150) is an antisense oligonucleotide that inhibits translation of STAT3, which is often activated by receptor tyrosine kinases including FGFR, thereby preventing cell proliferation (PMID: 23935373, PMID: 30661177).

DrugClasses STAT3 Inhibitor 26
CAS Registry Number 1402357-06-5
NCIT ID C101368

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Danvatirsen Acalabrutinib Danvatirsen 0 1
Carboplatin + Danvatirsen + Durvalumab Carboplatin Danvatirsen Durvalumab 0 0
Carboplatin + Danvatirsen + Durvalumab + Gemcitabine Carboplatin Danvatirsen Durvalumab Gemcitabine 0 1
Carboplatin + Danvatirsen + Durvalumab + Nab-paclitaxel Carboplatin Danvatirsen Durvalumab Nab-paclitaxel 0 1
Cisplatin + Danvatirsen + Durvalumab Cisplatin Danvatirsen Durvalumab 0 0
Cisplatin + Danvatirsen + Durvalumab + Fluorouracil Cisplatin Danvatirsen Durvalumab Fluorouracil 0 1
Cisplatin + Danvatirsen + Durvalumab + Gemcitabine Cisplatin Danvatirsen Durvalumab Gemcitabine 0 1
Danvatirsen Danvatirsen 0 2
Danvatirsen + Durvalumab Danvatirsen Durvalumab 0 8
Danvatirsen + Durvalumab + Gemcitabine Danvatirsen Durvalumab Gemcitabine 0 0
Danvatirsen + Durvalumab + Nab-paclitaxel Danvatirsen Durvalumab Nab-paclitaxel 0 0
Danvatirsen + Durvalumab + Paclitaxel Danvatirsen Durvalumab Paclitaxel 0 0
Danvatirsen + Durvalumab + Pemetrexed Disodium Danvatirsen Durvalumab Pemetrexed Disodium 0 0
Danvatirsen + Pembrolizumab Danvatirsen Pembrolizumab 0 1
Danvatirsen + Selumetinib Danvatirsen Selumetinib 0 0


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