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Drug Name | Xevinapant |
Trade Name | |
Synonyms | AT-406|SM-406|Debio1143|Debio-1143|Debio 1143 |
Drug Descriptions |
Xevinapant (debio 1143) is a SMAC mimetic, which antagonizes Inhibitor of Apoptosis Protein (IAP) family proteins, resulting in increased tumor cell apoptosis, decreased tumor growth (PMID: 21443232), and may reverse immunosuppression (PMID: 30352911, PMID: 32758455). |
DrugClasses | SMAC Mimetic 8 |
CAS Registry Number | 1071992-99-8 |
NCIT ID | C90574 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Avelumab + Xevinapant | Avelumab Xevinapant | 0 | 1 |
Carboplatin + Paclitaxel + Xevinapant | Carboplatin Paclitaxel Xevinapant | 0 | 1 |
Cetuximab + Xevinapant | Cetuximab Xevinapant | 0 | 1 |
Cisplatin + Xevinapant | Cisplatin Xevinapant | 0 | 3 |
Cytarabine + Daunorubicin + Xevinapant | Cytarabine Daunorubicin Xevinapant | 0 | 0 |
Nivolumab + Xevinapant | Nivolumab Xevinapant | 0 | 1 |
Pembrolizumab + Xevinapant | Pembrolizumab Xevinapant | 0 | 1 |
Xevinapant | Xevinapant | 0 | 4 |