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| Drug Name | Pralsetinib |
| Trade Name | Gavreto |
| Synonyms | BLU667|BLU-667 |
| Drug Descriptions |
Gavreto (pralsetinib) is a small molecule inhibitor that selectively targets activated Ret, which may result in antitumor activity including inhibition of tumor growth and tumor regression (PMID: 29657135). Gavreto (pralsetinib) is FDA approved for use in patients with metastatic RET fusion-positive non-small cell lung cancer, in adult and pediatric patients 12 years of age and older with advanced or metastatic RET-mutant medullary thyroid cancer, and in adult and pediatric patients 12 years of age and older with RET fusion-positive thyroid cancer who are radioactive iodine-refractory (FDA.gov). |
| DrugClasses | RET Inhibitor 53 |
| CAS Registry Number | 2097132-94-8 |
| NCIT ID | C132295 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Afatinib + Pralsetinib | Afatinib Pralsetinib | 0 | 0 |
| Crizotinib + Pralsetinib | Crizotinib Pralsetinib | 0 | 0 |
| Ensartinib + Pralsetinib | Ensartinib Pralsetinib | 0 | 0 |
| JC-010a + Pralsetinib | JC-010a Pralsetinib | 0 | 0 |
| Osimertinib + Pralsetinib | Osimertinib Pralsetinib | 0 | 0 |
| Palbociclib + Pralsetinib | Palbociclib Pralsetinib | 0 | 0 |
| Pralsetinib | Pralsetinib | 52 | 5 |
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