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Drug Name | Tinostamustine |
Trade Name | |
Synonyms | EDO-S101|EDOS101|EDO S101 |
Drug Descriptions |
Tinostamustine (EDO-S101) comprises the structure of the DNA alkylating drug bendumustine combined with the pan-HDAC inhibitor vorinostat, which may both induce DNA damage and inhibit DNA repair resulting in increased tumor cell death (PMID: 28753594, PMID: 32099034, PMID: 31372848). |
DrugClasses | Chemotherapy - Alkylating 18 HDAC Inhibitor 45 |
CAS Registry Number | 1236199-60-2 |
NCIT ID | C126105 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Bortezomib + Tinostamustine | Bortezomib Tinostamustine | 0 | 0 |
Carfilzomib + Tinostamustine | Carfilzomib Tinostamustine | 0 | 0 |
Delanzomib + Tinostamustine | Delanzomib Tinostamustine | 0 | 0 |
Marizomib + Tinostamustine | Marizomib Tinostamustine | 0 | 0 |
Tinostamustine | Tinostamustine | 0 | 5 |