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Drug Name | AZD5991 |
Trade Name | |
Synonyms | AZD-5991|AZD 5991 |
Drug Descriptions |
AZD5991 binds to and inhibits Mcl1, potentially resulting in increased tumor cell apoptosis and decreased tumor growth (Cancer Res July 1 2017 (77) (13 Supplement) DDT01-02, PMID: 32204955). |
DrugClasses | MCL1 Inhibitor 18 |
CAS Registry Number | 2143010-83-5 |
NCIT ID | C137989 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
AZD4320 + AZD5991 | AZD4320 AZD5991 | 0 | 0 |
AZD5991 | AZD5991 | 1 | 1 |
AZD5991 + AZD8186 | AZD5991 AZD8186 | 1 | 0 |
AZD5991 + Capivasertib | AZD5991 Capivasertib | 1 | 0 |
AZD5991 + Ruxolitinib | AZD5991 Ruxolitinib | 0 | 0 |
AZD5991 + Selumetinib | AZD5991 Selumetinib | 1 | 0 |
AZD5991 + Temozolomide | AZD5991 Temozolomide | 1 | 0 |
AZD5991 + Trametinib | AZD5991 Trametinib | 1 | 0 |
AZD5991 + Venetoclax | AZD5991 Venetoclax | 0 | 0 |