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Drug Name | AZD8186 |
Trade Name | |
Synonyms | AZD-8186|AZD 8186 |
Drug Descriptions |
AZD8186 selectively inhibits the activity of PI3Kbeta (PIK3CB) and delta (PIK3CD) in the PI3K/Akt/mTOR signaling pathway, which may result in decreased tumor cell proliferation (PMID: 25514658, PMID: 32194423). |
DrugClasses | PIK3CB inhibitor 8 PIK3CD inhibitor 27 |
CAS Registry Number | 1296270-45-5 |
NCIT ID | C107684 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Abiraterone + AZD8186 | AZD8186 Abiraterone | 0 | 1 |
Abiraterone + AZD8186 + Prednisone | AZD8186 Abiraterone Prednisone | 0 | 0 |
Alpelisib + AZD8186 | AZD8186 Alpelisib | 2 | 0 |
Alpelisib + AZD8186 + Enzalutamide | AZD8186 Alpelisib Enzalutamide | 1 | 0 |
AZD5991 + AZD8186 | AZD5991 AZD8186 | 1 | 0 |
AZD8186 | AZD8186 | 6 | 1 |
AZD8186 + Docetaxel | AZD8186 Docetaxel | 0 | 1 |
AZD8186 + Enzalutamide | AZD8186 Enzalutamide | 1 | 0 |
AZD8186 + SCH772984 | AZD8186 SCH772984 | 0 | 0 |
AZD8186 + Tipifarnib | AZD8186 Tipifarnib | 0 | 0 |
AZD8186 + Ulixertinib | AZD8186 Ulixertinib | 0 | 0 |
AZD8186 + Vistusertib | AZD8186 Vistusertib | 1 | 1 |