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Drug Name AB154
Trade Name
Synonyms AB-154|AB 154|Domvanalimab
Drug Descriptions

AB154 (domvanalimab) is a monoclonal antibody that targets T-cell immunoreceptor with Ig and ITIM domains (TIGIT), potentially resulting in enhanced immune response (Cancer Immunol Res 2019;7(2 Suppl):Abstract nr A124).

DrugClasses Immune Checkpoint Inhibitor 149 TIGIT Antibody 19
CAS Registry Number NA
NCIT ID C162875

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB154 AB154 0 2
AB154 + AB680 + Zimberelimab AB154 AB680 Zimberelimab 0 1
AB154 + Capecitabine + Oxaliplatin + Zimberelimab AB154 Capecitabine Oxaliplatin Zimberelimab 0 1
AB154 + Carboplatin + Nab-paclitaxel AB154 Carboplatin Nab-paclitaxel 0 1
AB154 + Carboplatin + Nab-paclitaxel + Zimberelimab AB154 Carboplatin Nab-paclitaxel Zimberelimab 0 1
AB154 + Carboplatin + Paclitaxel AB154 Carboplatin Paclitaxel 0 1
AB154 + Carboplatin + Paclitaxel + Zimberelimab AB154 Carboplatin Paclitaxel Zimberelimab 0 1
AB154 + Carboplatin + Pemetrexed Disodium AB154 Carboplatin Pemetrexed Disodium 0 1
AB154 + Carboplatin + Pemetrexed Disodium + Zimberelimab AB154 Carboplatin Pemetrexed Disodium Zimberelimab 0 1
AB154 + Cisplatin + Pemetrexed Disodium AB154 Cisplatin Pemetrexed Disodium 0 1
AB154 + Cisplatin + Pemetrexed Disodium + Zimberelimab AB154 Cisplatin Pemetrexed Disodium Zimberelimab 0 1
AB154 + Docetaxel + Zimberelimab AB154 Docetaxel Zimberelimab 0 1
AB154 + Durvalumab AB154 Durvalumab 0 1
AB154 + Etrumadenant + Zimberelimab AB154 Etrumadenant Zimberelimab 0 3
AB154 + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab AB154 Fluorouracil Leucovorin Oxaliplatin Zimberelimab 0 2
AB154 + Sacituzumab govitecan-hziy + Zimberelimab AB154 Sacituzumab govitecan-hziy Zimberelimab 0 2
AB154 + Sotigalimab + Zimberelimab AB154 Sotigalimab Zimberelimab 0 1
AB154 + Zimberelimab AB154 Zimberelimab 0 8


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