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| Drug Name | Sacituzumab govitecan-hziy |
| Trade Name | Trodelvy |
| Synonyms | IMMU-132|Sactizumab|Sacituzumab govitecan |
| Drug Descriptions |
Trodelvy (sacituzumab govitecan-hziy) is an antibody-drug conjugate (ADC) composed of a monoclonal anti-TROP2 antibody linked to the active metabolite of irinotecan (SN-38), which binds to TROP2 positive cancer cells and induces DNA breakage and apoptosis (PMID: 26541586). Trodelvy (sacituzumab govitecan-hziy) is FDA approved for use in patients with metastatic triple-negative breast cancer who received two or more prior therapies, in patients with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer who have received endocrine-based therapy and at least two additional systemic therapies, and in patients with locally advanced or metastatic urothelial cancer who received a platinum-containing chemotherapy and a PD-1 or PD-L1 inhibitor (FDA.gov). |
| DrugClasses | TROP2 Antibody 13 |
| CAS Registry Number | 1491917-83-9 |
| NCIT ID | C102783 |
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