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Drug Name | CC-99282 |
Trade Name | |
Synonyms | CC99282|CC 99282|BMS-986369|BMS986369|BMS 986369|Golcadomide |
Drug Descriptions |
CC-99282 modulates cereblon E3 ubiquitin ligase, leading to degradation of the transcription factors Ikaros and Aiolos, potentially resulting in decreased tumor cell proliferation, enhanced apoptosis, and antitumor activity (Blood (2021) 138 (Supplement 1). |
DrugClasses | |
CAS Registry Number | 953769-46-5 |
NCIT ID | C172396 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
CC-99282 | CC-99282 | 0 | 2 |
CC-99282 + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate | CC-99282 Cyclophosphamide Doxorubicin Prednisone Rituximab Vincristine Sulfate | 0 | 2 |
CC-99282 + Glofitamab-gxbm | CC-99282 Glofitamab-gxbm | 0 | 1 |
CC-99282 + Mosunetuzumab-axgb | CC-99282 Mosunetuzumab-axgb | 0 | 1 |
CC-99282 + Nivolumab + Rituximab | CC-99282 Nivolumab Rituximab | 0 | 1 |
CC-99282 + Obinutuzumab | CC-99282 Obinutuzumab | 0 | 2 |
CC-99282 + Rituximab | CC-99282 Rituximab | 0 | 4 |