Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name CC-99282
Trade Name
Synonyms CC99282|CC 99282|BMS-986369|BMS986369|BMS 986369|Golcadomide
Drug Descriptions

CC-99282 modulates cereblon E3 ubiquitin ligase, leading to degradation of the transcription factors Ikaros and Aiolos, potentially resulting in decreased tumor cell proliferation, enhanced apoptosis, and antitumor activity (Blood (2021) 138 (Supplement 1).

DrugClasses
CAS Registry Number 953769-46-5
NCIT ID C172396

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
CC-99282 CC-99282 0 2
CC-99282 + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate CC-99282 Cyclophosphamide Doxorubicin Prednisone Rituximab Vincristine Sulfate 0 2
CC-99282 + Glofitamab-gxbm CC-99282 Glofitamab-gxbm 0 1
CC-99282 + Mosunetuzumab-axgb CC-99282 Mosunetuzumab-axgb 0 1
CC-99282 + Nivolumab + Rituximab CC-99282 Nivolumab Rituximab 0 1
CC-99282 + Obinutuzumab CC-99282 Obinutuzumab 0 2
CC-99282 + Rituximab CC-99282 Rituximab 0 4


Additional content available in CKB BOOST