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Drug Name | Polatuzumab vedotin-piiq |
Trade Name | Polivy |
Synonyms | ADC DCDS4501A|DCDS4501A|FCU 2711|RG7596|Ro 5541077-000|Polatuzumab Vedotin |
Drug Descriptions |
Polivy (polatuzumab vedotin-piiq) is a monoclonal antibody against B-cell antigen receptor complex-associated protein beta chain (CD79B) linked to monomethyl auristatin E (MMAE), which may deliver the cytotoxic MMAE to tumor cells over expressing CD79b (PMID: 26194424). Polivy (polatuzumab vedotin-piiq) is FDA-approved for use in combination with Treanda (bendamustine) and Rituxan (rituximab) in patients with relapsed or refractory diffuse large B-cell lymphoma after 2 or more prior therapies, and in combination with R-CHP in patients with untreated diffuse large B-cell lymphoma, not otherwise specified (NOS), or high-grade B-cell lymphoma with an IPI score of 2 or greater (FDA.gov). |
DrugClasses | |
CAS Registry Number | 1313206-42-6 |
NCIT ID | C104153 |