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Drug Name Polatuzumab vedotin-piiq
Trade Name Polivy
Synonyms ADC DCDS4501A|DCDS4501A|FCU 2711|RG7596|Ro 5541077-000|Polatuzumab Vedotin
Drug Descriptions

Polivy (polatuzumab vedotin-piiq) is a monoclonal antibody against B-cell antigen receptor complex-associated protein beta chain (CD79B) linked to monomethyl auristatin E (MMAE), which may deliver the cytotoxic MMAE to tumor cells over expressing CD79b (PMID: 26194424). Polivy (polatuzumab vedotin-piiq) is FDA-approved for use in combination with Treanda (bendamustine) and Rituxan (rituximab) in patients with relapsed or refractory diffuse large B-cell lymphoma after 2 or more prior therapies, and in combination with R-CHP in patients with untreated diffuse large B-cell lymphoma, not otherwise specified (NOS), or high-grade B-cell lymphoma with an IPI score of 2 or greater (FDA.gov).

DrugClasses
CAS Registry Number 1313206-42-6
NCIT ID C104153

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Obinutuzumab + Polatuzumab vedotin-piiq Atezolizumab Obinutuzumab Polatuzumab vedotin-piiq 0 1
Bendamustine + Iberdomide + Polatuzumab vedotin-piiq + Rituximab Bendamustine Iberdomide Polatuzumab vedotin-piiq Rituximab 0 0
Bendamustine + Polatuzumab vedotin-piiq + Rituximab Bendamustine Polatuzumab vedotin-piiq Rituximab 0 6
Bendamustine + Polatuzumab vedotin-piiq + Rituximab + Selinexor Bendamustine Polatuzumab vedotin-piiq Rituximab Selinexor 0 1
Carboplatin + Etoposide + Ifosfamide + Polatuzumab vedotin-piiq + Rituximab Carboplatin Etoposide Ifosfamide Polatuzumab vedotin-piiq Rituximab 0 2
Cisplatin + Dexamethasone + Gemcitabine + Hyaluronidase + Polatuzumab vedotin-piiq + Rituximab + Sargramostim Cisplatin Dexamethasone Gemcitabine Hyaluronidase Polatuzumab vedotin-piiq Rituximab Sargramostim 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Hydrocortisone + Methotrexate + Polatuzumab vedotin-piiq + Rituximab Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Hydrocortisone Methotrexate Polatuzumab vedotin-piiq Rituximab 0 0
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Hydrocortisone Sodium Succinate + Methotrexate + Polatuzumab vedotin-piiq Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Hydrocortisone Sodium Succinate Methotrexate Polatuzumab vedotin-piiq 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Hydrocortisone Sodium Succinate + Methotrexate + Polatuzumab vedotin-piiq + Rituximab Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Hydrocortisone Sodium Succinate Methotrexate Polatuzumab vedotin-piiq Rituximab 0 1
Cyclophosphamide + Doxorubicin + Epcoritamab-bysp + Polatuzumab vedotin-piiq + Prednisone + Rituximab Cyclophosphamide Doxorubicin Epcoritamab-bysp Polatuzumab vedotin-piiq Prednisone Rituximab 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Filgrastim + Polatuzumab vedotin-piiq + Prednisone + Rituximab Cyclophosphamide Doxorubicin Etoposide Filgrastim Polatuzumab vedotin-piiq Prednisone Rituximab 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Polatuzumab vedotin-piiq + Prednisone + Rituximab Cyclophosphamide Doxorubicin Etoposide Polatuzumab vedotin-piiq Prednisone Rituximab 0 1
Cyclophosphamide + Doxorubicin + Glofitamab-gxbm + Polatuzumab vedotin-piiq + Prednisolone + Rituximab Cyclophosphamide Doxorubicin Glofitamab-gxbm Polatuzumab vedotin-piiq Prednisolone Rituximab 0 1
Cyclophosphamide + Doxorubicin + Glofitamab-gxbm + Polatuzumab vedotin-piiq + Prednisone + Rituximab Cyclophosphamide Doxorubicin Glofitamab-gxbm Polatuzumab vedotin-piiq Prednisone Rituximab 0 2
Cyclophosphamide + Doxorubicin + Methylprednisolone + Polatuzumab vedotin-piiq + Rituximab Cyclophosphamide Doxorubicin Methylprednisolone Polatuzumab vedotin-piiq Rituximab 0 1
Cyclophosphamide + Doxorubicin + Mosunetuzumab-axgb + Polatuzumab vedotin-piiq + Prednisone Cyclophosphamide Doxorubicin Mosunetuzumab-axgb Polatuzumab vedotin-piiq Prednisone 0 2
Cyclophosphamide + Doxorubicin + Parsaclisib + Pegfilgrastim + Polatuzumab vedotin-piiq + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Parsaclisib Pegfilgrastim Polatuzumab vedotin-piiq Prednisone Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Polatuzumab vedotin-piiq Cyclophosphamide Doxorubicin Polatuzumab vedotin-piiq 0 1
Cyclophosphamide + Doxorubicin + Polatuzumab vedotin-piiq + Prednisolone + Rituximab Cyclophosphamide Doxorubicin Polatuzumab vedotin-piiq Prednisolone Rituximab 0 1
Cyclophosphamide + Doxorubicin + Polatuzumab vedotin-piiq + Prednisone + Rituximab Cyclophosphamide Doxorubicin Polatuzumab vedotin-piiq Prednisone Rituximab 0 4
Cyclophosphamide + Doxorubicin + Polatuzumab vedotin-piiq + Prednisone + Rituximab + Venetoclax Cyclophosphamide Doxorubicin Polatuzumab vedotin-piiq Prednisone Rituximab Venetoclax 0 1
Cytarabine + Etoposide + Hydrocortisone Sodium Succinate + Methotrexate + Polatuzumab vedotin-piiq + Rituximab Cytarabine Etoposide Hydrocortisone Sodium Succinate Methotrexate Polatuzumab vedotin-piiq Rituximab 0 0
Cytarabine + Etoposide + Polatuzumab vedotin-piiq Cytarabine Etoposide Polatuzumab vedotin-piiq 0 1
Cytarabine + Etoposide + Polatuzumab vedotin-piiq + Rituximab Cytarabine Etoposide Polatuzumab vedotin-piiq Rituximab 0 1
Gemcitabine + Oxaliplatin + Polatuzumab vedotin-piiq + Rituximab Gemcitabine Oxaliplatin Polatuzumab vedotin-piiq Rituximab 0 1
Glofitamab-gxbm + Obinutuzumab + Polatuzumab vedotin-piiq Glofitamab-gxbm Obinutuzumab Polatuzumab vedotin-piiq 0 2
Glofitamab-gxbm + Obinutuzumab + Polatuzumab vedotin-piiq + Rituximab Glofitamab-gxbm Obinutuzumab Polatuzumab vedotin-piiq Rituximab 0 1
Glofitamab-gxbm + Obinutuzumab + Polatuzumab vedotin-piiq + Tocilizumab Glofitamab-gxbm Obinutuzumab Polatuzumab vedotin-piiq Tocilizumab 0 1
Iberdomide + Polatuzumab vedotin-piiq + Rituximab Iberdomide Polatuzumab vedotin-piiq Rituximab 0 1
Ibrutinib + Lenalidomide + Obinutuzumab + Polatuzumab vedotin-piiq + Prednisone + Venetoclax Ibrutinib Lenalidomide Obinutuzumab Polatuzumab vedotin-piiq Prednisone Venetoclax 0 1
Lenalidomide + Mosunetuzumab-axgb + Polatuzumab vedotin-piiq Lenalidomide Mosunetuzumab-axgb Polatuzumab vedotin-piiq 0 1
Lenalidomide + Mosunetuzumab-axgb + Polatuzumab vedotin-piiq + Tafasitamab-cxix Lenalidomide Mosunetuzumab-axgb Polatuzumab vedotin-piiq Tafasitamab-cxix 0 1
Lenalidomide + Obinutuzumab + Polatuzumab vedotin-piiq Lenalidomide Obinutuzumab Polatuzumab vedotin-piiq 0 1
Lenalidomide + Polatuzumab vedotin-piiq + Rituximab Lenalidomide Polatuzumab vedotin-piiq Rituximab 0 1
Loncastuximab tesirine-lpyl + Polatuzumab vedotin-piiq Loncastuximab tesirine-lpyl Polatuzumab vedotin-piiq 0 1
Mosunetuzumab-axgb + Obinutuzumab + Polatuzumab vedotin-piiq Mosunetuzumab-axgb Obinutuzumab Polatuzumab vedotin-piiq 0 1
Mosunetuzumab-axgb + Polatuzumab vedotin-piiq Mosunetuzumab-axgb Polatuzumab vedotin-piiq 0 6
Mosunetuzumab-axgb + Polatuzumab vedotin-piiq + Tocilizumab Mosunetuzumab-axgb Polatuzumab vedotin-piiq Tocilizumab 0 1
Obinutuzumab + Polatuzumab vedotin-piiq Obinutuzumab Polatuzumab vedotin-piiq 0 1
Obinutuzumab + Polatuzumab vedotin-piiq + Rituximab Obinutuzumab Polatuzumab vedotin-piiq Rituximab 0 1
Obinutuzumab + Polatuzumab vedotin-piiq + Venetoclax Obinutuzumab Polatuzumab vedotin-piiq Venetoclax 0 1
Pinatuzumab Vedotin + Polatuzumab vedotin-piiq + Rituximab Pinatuzumab Vedotin Polatuzumab vedotin-piiq Rituximab 0 1
Polatuzumab vedotin-piiq Polatuzumab vedotin-piiq 0 6
Polatuzumab vedotin-piiq + Rituximab Polatuzumab vedotin-piiq Rituximab 0 0
Polatuzumab vedotin-piiq + Rituximab + Rituximab Hyaluronidase + Venetoclax Polatuzumab vedotin-piiq Rituximab Rituximab Hyaluronidase Venetoclax 0 1
Polatuzumab vedotin-piiq + Rituximab + Selinexor Polatuzumab vedotin-piiq Rituximab Selinexor 0 1
Polatuzumab vedotin-piiq + Rituximab + Venetoclax Polatuzumab vedotin-piiq Rituximab Venetoclax 0 1


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