Gene Variant Detail

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT05244551	Phase I	ABSK061	A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK061 in Patients With Advanced Solid Tumors	Recruiting	USA	1
NCT02546661	Phase I	Danvatirsen + Durvalumab Durvalumab + Selumetinib Fexagratinib Durvalumab + Olaparib Durvalumab Durvalumab + Fexagratinib Durvalumab + Vistusertib Adavosertib + Durvalumab	Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer (BISCAY)	Active, not recruiting	USA \| GBR \| FRA \| ESP \| CAN	0
NCT02608125	Phase I	PRN1371	A Dose Escalation Study in Solid Tumors and a Dose Expansion Study of PRN1371 in Adult Patients With Metastatic Urothelial Carcinoma	Terminated	USA \| ESP	0
NCT06653777	Phase II	Pemigatinib	Efficacy of Pemigatinib in Patients With Solid Tumors Characterized by an Alteration of the Gene FGFR in Tumor Cells (AcSe PEMI)	Not yet recruiting	FRA	0
NCT04233567	Phase II	Infigratinib	Infigratinib for the Treatment of Advanced or Metastatic Solid Tumors in Patients With FGFR Gene Mutations	Active, not recruiting	USA	0
NCT04972253	Phase I	Infigratinib	Phase I BLASST-3 Trial ((BLASST)-3)	Withdrawn		0
NCT06302621	Phase I	Afatinib + Pemigatinib	Pemigatinib + Afatinib in Advanced Refractory Solid Tumors	Recruiting	USA	0
NCT05216120	Phase II	Pemigatinib	Pemigatinib in Subjects With Adenosquamous Carcinoma of the Pancreas	Withdrawn	USA	0
NCT02160041	Phase II	Infigratinib	BGJ398 for Patients With Tumors With FGFR Genetic Alterations	Terminated	USA	0
NCT05316155	Phase I	Erdafitinib	Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer	Recruiting	USA \| NLD \| ESP \| DEU	1
NCT02393248	Phase Ib/II	Cisplatin + Gemcitabine + Pemigatinib Docetaxel + Pemigatinib Pemigatinib + Retifanlimab Pemigatinib + Trastuzumab Epacadostat + Pembrolizumab	Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)	Terminated	USA \| DNK	0
NCT05627063	Phase I	ABSK121	A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK121-NX in Patients With Advanced Solid Tumors	Recruiting	USA	1
NCT05544552	Phase Ib/II	TYRA-300	Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations (SURF301)	Recruiting	USA \| FRA \| ESP \| AUS	0
NCT05253807	Phase II	Pemigatinib	Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Relapsed or Refractory Advanced Non-Small Cell Lung Cancer With an FGFR Alteration (FIGHT-210)	Completed	USA \| ITA \| FRA \| ESP \| DEU	0
NCT02052778	Phase Ib/II	Futibatinib	A Study of TAS-120 in Patients With Advanced Solid Tumors	Completed	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| AUS	4
NCT05614739	Phase I	LOXO-435 + Pembrolizumab LOXO-435	A Study of LOXO-435 in Participants With Cancer With a Change in a Gene Called FGFR3	Recruiting	USA \| NOR \| NLD \| ITA \| ISR \| GBR \| FRA \| ESP \| DEU \| CAN \| AUS	3
NCT04917809	Phase II	Erdafitinib	A Study of Oral Erdafitinib in People With Recurrent Non-Invasive Bladder Cancer	Recruiting	USA	0
NCT02272998	Phase II	Ponatinib	Ponatinib for Patients Whose Advanced Solid Tumor Cancer Has Activating Mutations Involving the Following Genes: FGFR1, FGFR2, FGFR3, FGFR4, RET, KIT.	Active, not recruiting	USA	0
NCT01948297	Phase I	Zoligratinib	Debio 1347-101 Phase I Trial in Advanced Solid Tumours With Fibroblast Growth Factor Receptor (FGFR) Alterations	Terminated	USA \| ESP	3
NCT02872714	Phase II	Pemigatinib	A Study to Evaluate the Efficacy and Safety of Pemigatinib (INCB054828) in Subjects With Urothelial Carcinoma - (FIGHT-201)	Completed	USA \| NLD \| ITA \| ISR \| GBR \| FRA \| ESP \| DNK \| DEU \| BEL	1
NCT05267106	Phase II	Pemigatinib	Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations (FIGHT-209)	Active, not recruiting	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DNK \| DEU	1
NCT04088188	Phase I	Cisplatin + Gemcitabine + Pemigatinib Cisplatin + Gemcitabine + Ivosidenib	Gemcitabine and Cisplatin With Ivosidenib or Pemigatinib for the Treatment of Unresectable or Metastatic Cholangiocarcinoma	Terminated	USA	0
NCT06319820	Phase III	Mitomycin C Gemcitabine Erdafitinib	A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer (MoonRISe-1)	Recruiting	USA \| TUR \| POL \| ITA \| ISR \| GBR \| FRA \| ESP \| DNK \| DEU \| CZE \| BRA \| BEL \| AUT \| ARG	4
NCT04083976	Phase II	Erdafitinib	A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations (RAGNAR)	Active, not recruiting	USA \| POL \| ITA \| GBR \| FRA \| ESP \| DEU \| BRA \| BEL \| AUS \| ARG	4
NCT06160752	Phase I	TYRA-200	Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations (SURF201)	Recruiting	USA	0
NCT04601857	Phase II	Futibatinib + Pembrolizumab	Futibatinib and Pembrolizumab Combination in the Treatment of Advanced or Metastatic Urothelial Carcinoma	Active, not recruiting	USA \| FRA \| ESP	0
NCT04197986	Phase III	Infigratinib	Study of Oral Infigratinib for the Adjuvant Treatment of Subjects With Invasive Urothelial Carcinoma With Susceptible FGFR3 Genetic Alterations	Terminated	USA \| NLD \| ITA \| GRC \| GBR \| FRA \| ESP \| DEU \| CAN \| BGR \| BEL	0
NCT02657486	Phase 0	Infigratinib	BGJ398 in Non-Muscle-Invasive Urothelial Carcinoma of the Bladder	Active, not recruiting	USA	0
NCT03390504	Phase III	Pembrolizumab Erdafitinib Docetaxel + Vinflunine	A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations (THOR)	Active, not recruiting	USA \| TUR \| POL \| NLD \| ITA \| ISR \| HUN \| GRC \| GBR \| FRA \| ESP \| DEU \| CAN \| BRA \| BGR \| BEL \| AUT \| AUS \| ARG	8
NCT03822117	Phase II	Pemigatinib	Efficacy and Safety of Pemigatinib in Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)	Terminated	USA \| ITA \| ISR \| GBR \| FRA \| ESP \| DNK \| DEU \| CHE	2
NCT03834220	Phase II	Zoligratinib	Basket Trial in Solid Tumors Harboring a Fusion of FGFR1, FGFR2 or FGFR3- (FUZE Clinical Trial)	Terminated	USA \| ROU \| POL \| NOR \| NLD \| HRV \| GRC \| GBR \| FRA \| FIN \| ESP \| DNK \| CZE \| BRA \| BGR \| AUT \| AUS	6
NCT04045613	Phase Ib/II	Derazantinib Atezolizumab + Derazantinib	Derazantinib and Atezolizumab in Patients With Urothelial Cancer (FIDES-02)	Completed	USA \| POL \| ITA \| HUN \| GBR \| FRA \| ESP \| DEU \| CZE \| CHE \| CAN \| AUT \| AUS	1
NCT04172675	Phase II	Erdafitinib Gemcitabine Mitomycin C	A Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Participants Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC)	Active, not recruiting	USA \| POL \| ITA \| GBR \| FRA \| ESP \| DEU \| CZE \| BRA \| BEL \| AUS \| ARG	5

Gene	FGFR3
Variant	fusion
Impact List	fusion
Protein Effect	unknown
Gene Variant Descriptions	FGFR3 fusion indicates a fusion of the FGFR3 gene, but the fusion partner is unknown.
Associated Drug Resistance
Category Variants Paths	FGFR3 mutant FGFR3 rearrange FGFR3 fusion

Gene Variant Detail

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