Therapy Detail

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Therapy Name Tepotinib
Synonyms
Therapy Description

Tepmetko (tepotinib) selectively binds to the proto-oncogene hepatocyte growth factor receptor (HGFR or c-Met), which inhibits c-Met phosphorylation and disrupts c-Met-mediated signaling pathways, thereby suppressing tumor growth in tumor cells with activated or overexpression of c-Met protein (PMID: 32328660). Tepmetko (tepotinib) is FDA approved for use in patients with metastatic non-small cell lung cancer harboring MET exon 14 skipping mutations (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tepotinib Tepmetko EMD1214063|EMD-1214063|EMD 1214063|MSC2156119|MSC-2156119|MSC2156119J MET Inhibitor 59 Tepmetko (tepotinib) selectively binds to the proto-oncogene hepatocyte growth factor receptor (HGFR or c-Met), which inhibits c-Met phosphorylation and disrupts c-Met-mediated signaling pathways, thereby suppressing tumor growth in tumor cells with activated or overexpression of c-Met protein (PMID: 32328660). Tepmetko (tepotinib) is FDA approved for use in patients with metastatic non-small cell lung cancer harboring MET exon 14 skipping mutations (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02864992 Phase II Tepotinib Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION) Active, not recruiting USA | POL | NLD | ITA | ISR | FRA | ESP | DEU | CHE | BEL | AUT 4
NCT05159245 Phase II Vemurafenib Tepotinib Vismodegib Apalutamide Alectinib Regorafenib Entrectinib Pertuzumab + Trastuzumab Pemigatinib Atezolizumab Cobimetinib Dabrafenib + Trametinib Dabrafenib Trametinib Abemaciclib The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs (FINPROVE) Recruiting FIN 0
NCT04739358 Phase Ib/II Tepotinib CNS Dose Escalation/Expansion of Tepotinib in MET-driven NSCLC Terminated USA 0
NCT06031688 Phase II Tepotinib Ramucirumab + Tepotinib Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial) Recruiting USA 0
NCT01014936 Phase I Tepotinib First-in-Man, Dose-escalation Trial of C-met Kinase Inhibitor MSC2156119J in Subjects With Advanced Solid Tumors Completed USA 0
NCT03940703 Phase II Osimertinib + Tepotinib Tepotinib A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2) Active, not recruiting USA | NLD | ITA | FRA | ESP | DEU | BEL 10
NCT05120960 Phase I Tepotinib Osimertinib + Tepotinib A Phase 1a/1b Study to Determine the Recommended Phase 2 Dose, of Tepotinib in Participants With MET Alterations and Brain Tumors Withdrawn 0


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