We’re improving your experience!

Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.

Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.

Stay tuned for these updates, and thank you for being part of our community!

CTNNB1 T41A - Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene CTNNB1
Variant T41A
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions CTNNB1 T41A lies within a Gsk3b phosphorylation site of the Ctnnb1 protein (UniProt.org). T41A confers a gain of function to the Ctnnb1 protein as demonstrated by nuclear accumulation of Ctnnb1 and increased Ctnnb1-dependent transcription (PMID: 10698519, PMID: 10487827, PMID: 12200448).
Associated Drug Resistance
Category Variants Paths

CTNNB1 mutant CTNNB1 act mut CTNNB1 T41A

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_001098210.2
gDNA chr3:g.41224633A>G
cDNA c.121A>G
Protein p.T41A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006712985.2 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
NM_001904 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
NM_001098210.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_047447478.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_024453357.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
NM_001098209 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_006712985.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_024453358.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
NM_001904.4 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_047447477.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_047447481.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_047447480.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
NM_001098210.2 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_047447483.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_024453356.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_006712985 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_017005738.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
NM_001098209.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_017005738.2 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_024453356.2 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
NM_001098209.2 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_005264886 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
XM_047447479.1 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
NM_001098210 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38
NM_001904.3 chr3:g.41224633A>G c.121A>G p.T41A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 T41A desmoid tumor sensitive Imatinib Clinical Study - Cohort Actionable In a retrospective analysis, patients with desmoid fibromatosis harboring CTNNB1 T41A demonstrated a greater progression arrest rate at 6 months (70%) compared to patients with CTNNB1 wild-type (45%) when treated with Gleevec (imatinib) (PMID: 26861905). 26861905
CTNNB1 T41A lung cancer predicted - sensitive NTRC 0066-0 Preclinical - Cell line xenograft Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to NTRC 0066-0 compared to cell lines with wild-type CTNNB1, in culture and in xenograft models (PMID: 28751540). 28751540
CTNNB1 T41A lung cancer predicted - sensitive Mps-BAY2b Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to Mps-BAY2b compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 T41A lung cancer predicted - sensitive NMS-P715 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 T41A lung cancer predicted - sensitive BAY1161909 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 T41A lung cancer predicted - sensitive BAY1217389 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to BAY1217389 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 T41A lung cancer predicted - sensitive Mps1-IN-1 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to Mps1-IN-1 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 T41A lung cancer predicted - sensitive MPI-0479605 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A demonstrated increased sensitivity to MPI-0479605 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 T41A colorectal cancer resistant Cetuximab Preclinical - Cell culture Actionable In a preclinical study, a colorectal cancer cell line expressing CTNNB1 T41A was resistant to treatment with Erbitux (cetuximab) in culture (PMID: 33574948). 33574948
CTNNB1 T41A desmoid tumor predicted - sensitive BMS-906024 Case Reports/Case Series Actionable In a Phase I trial, BMS-906024 treatment resulted in a partial response that lasted for 3.6 years on treatment and at least another 4 years after the end of treatment in a patient with a desmoid tumor harboring CTNNB1 T41A (PMID: 34590610; NCT01292655). 34590610
CTNNB1 T41A hepatocellular carcinoma sensitive WNTinib Preclinical - Patient cell culture Actionable In a preclinical study, WNTinib inhibited Ezh2 phosphorylation and viability in patient-derived hepatocellular carcinoma cell lines harboring CTNNB1 T41A in culture (PMID: 37537299). 37537299