Molecular Profile Detail

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
CBL mutant	myelodysplastic/myeloproliferative neoplasm	not applicable	N/A	Clinical Study	Prognostic	In clinical analyses, mutations in CBL were associated with adverse prognosis in patients with chronic myelomonocytic leukemia (PMID: 26230957, PMID: 23690417, PMID: 19901108).	26230957 19901108 23690417
CBL mutant	bone marrow cancer	sensitive	Quizartinib	Preclinical	Actionable	In a preclinical study, Vanflyta (quizartinib) reduced white blood cell counts and decreased myeloid cell invasion in a CBL mutant mouse model with myeloproliferative disorder (PMID: 22990016).	22990016
CBL mutant	myelofibrosis	not applicable	N/A	Guideline	Prognostic	CBL mutations are associated with inferior overall survival in patients with primary myelofibrosis (NCCN.org).	detail...
CBL mutant	systemic mastocytosis	not applicable	N/A	Guideline	Prognostic	CBL mutations are associated with an adverse prognosis in patients with systemic mastocytosis (NCCN.org).	detail...

Profile Name	CBL Q875*
Gene Variant Detail	CBL Q875* (unknown)
Relevant Treatment Approaches