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Ref Type Journal Article
PMID (22662154)
Authors Shoji K, Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, Miyamoto Y, Hiraike H, Tanikawa M, Miyasaka A, Koso T, Matsumoto Y, Wada-Hiraike O, Kawana K, Kuramoto H, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y
Title Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas.
URL
Abstract Text The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently activated in endometrial cancer through various PI3K/AKT-activating genetic alterations. We examined the antitumor effect of NVP-BEZ235--a dual PI3K/mTOR inhibitor--and RAD001--an mTOR inhibitor--in 13 endometrial cancer cell lines, all of which possess one or more alterations in PTEN, PIK3CA, and K-Ras. We also combined these compounds with a MAPK pathway inhibitor (PD98059 or UO126) in cell lines with K-Ras alterations (mutations or amplification). PTEN mutant cell lines without K-Ras alterations (n = 9) were more sensitive to both RAD001 and NVP-BEZ235 than were cell lines with K-Ras alterations (n = 4). Dose-dependent growth suppression was more drastically induced by NVP-BEZ235 than by RAD001 in the sensitive cell lines. G1 arrest was induced by NVP-BEZ235 in a dose-dependent manner. We observed in vivo antitumor activity of both RAD001 and NVP-BEZ235 in nude mice. The presence of a MEK inhibitor, PD98059 or UO126, sensitized the K-Ras mutant cells to NVP-BEZ235. Robust growth suppression by NVP-BEZ235 suggests that a dual PI3K/mTOR inhibitor is a promising therapeutic for endometrial carcinomas. Our data suggest that mutational statuses of PTEN and K-Ras might be useful predictors of sensitivity to NVP-BEZ235 in certain endometrial carcinomas.

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Molecular Profile Treatment Approach
PTEN C136fs PI3K Inhibitor (Pan)
PTEN Y65C PI3K Inhibitor (Pan)
PTEN Y68N PI3K Inhibitor (Pan)
PTEN E18* PI3K Inhibitor (Pan)
PTEN Q17Kfs*7 PI3K Inhibitor (Pan)
PTEN E7* PI3K Inhibitor (Pan)
PTEN A126P PI3K Inhibitor (Pan)
PTEN E242* PI3K Inhibitor (Pan)
PTEN W274* PI3K Inhibitor (Pan)
PTEN K267* PI3K Inhibitor (Pan)
PTEN Y68* PI3K Inhibitor (Pan)
PTEN Y155C PI3K Inhibitor (Pan)
PTEN H141P PI3K Inhibitor (Pan)
PTEN S170N PI3K Inhibitor (Pan)
PTEN G127E PI3K Inhibitor (Pan)
PTEN S10I PI3K Inhibitor (Pan)
PTEN K163* PI3K Inhibitor (Pan)
PTEN R173P PI3K Inhibitor (Pan)
PTEN C124S PI3K Inhibitor (Pan)
PTEN Y46D PI3K Inhibitor (Pan)
PTEN A126G PI3K Inhibitor (Pan)
PTEN I122F PI3K Inhibitor (Pan)
PTEN D52del PI3K Inhibitor (Pan)
PTEN E242fs PI3K Inhibitor (Pan)
PTEN N117S PI3K Inhibitor (Pan)
PTEN D331fs PI3K Inhibitor (Pan)
PTEN Y65S PI3K Inhibitor (Pan)
PTEN S170I PI3K Inhibitor (Pan)
PTEN S170R PI3K Inhibitor (Pan)
PTEN R172fs PI3K Inhibitor (Pan)
PTEN P96del PI3K Inhibitor (Pan)
PTEN E291* PI3K Inhibitor (Pan)
PTEN F90Lfs*90 PI3K Inhibitor (Pan)
PTEN Q245* PI3K Inhibitor (Pan)
PTEN L182fs PI3K Inhibitor (Pan)
PTEN F341V PI3K Inhibitor (Pan)
PTEN M134L PI3K Inhibitor (Pan)
PTEN K197* PI3K Inhibitor (Pan)
PTEN Y27D PI3K Inhibitor (Pan)
PTEN G129D PI3K Inhibitor (Pan)
PTEN Q298fs PI3K Inhibitor (Pan)
PTEN Y177D PI3K Inhibitor (Pan)
PTEN P95L PI3K Inhibitor (Pan)
PTEN C250fs PI3K Inhibitor (Pan)
PTEN Y240* PI3K Inhibitor (Pan)
PTEN K6fs PI3K Inhibitor (Pan)
PTEN E157* PI3K Inhibitor (Pan)
PTEN W111S PI3K Inhibitor (Pan)
PTEN L42P PI3K Inhibitor (Pan)
PTEN P38F PI3K Inhibitor (Pan)
PTEN G251V PI3K Inhibitor (Pan)
PTEN P339L PI3K Inhibitor (Pan)
PTEN I122N PI3K Inhibitor (Pan)
PTEN D22E PI3K Inhibitor (Pan)
PTEN P38H PI3K Inhibitor (Pan)
PTEN Y174N PI3K Inhibitor (Pan)
PTEN T160I PI3K Inhibitor (Pan)
PTEN R130Q PI3K Inhibitor (Pan)
PTEN K60fs PI3K Inhibitor (Pan)
PTEN G127* PI3K Inhibitor (Pan)
PTEN I33del PI3K Inhibitor (Pan)
PTEN H123R PI3K Inhibitor (Pan)
PTEN R161G PI3K Inhibitor (Pan)
PTEN C124fs PI3K Inhibitor (Pan)
PTEN L325F PI3K Inhibitor (Pan)
PTEN M134R PI3K Inhibitor (Pan)
PTEN L57fs PI3K Inhibitor (Pan)
PTEN K6I PI3K Inhibitor (Pan)
PTEN L57W PI3K Inhibitor (Pan)
PTEN I135K PI3K Inhibitor (Pan)
PTEN S338fs PI3K Inhibitor (Pan)
PTEN P38T PI3K Inhibitor (Pan)
PTEN H61K PI3K Inhibitor (Pan)
PTEN G132D PI3K Inhibitor (Pan)
PTEN L57* PI3K Inhibitor (Pan)
PTEN N323fs PI3K Inhibitor (Pan)
PTEN V54fs PI3K Inhibitor (Pan)
PTEN L152R PI3K Inhibitor (Pan)
PTEN E201* PI3K Inhibitor (Pan)
PTEN A126fs PI3K Inhibitor (Pan)
PTEN G165V PI3K Inhibitor (Pan)
PTEN T319fs PI3K Inhibitor (Pan)
PTEN N212Kfs*10 PI3K Inhibitor (Pan)
PTEN N276S PI3K Inhibitor (Pan)
PTEN E285* PI3K Inhibitor (Pan)
PTEN K260fs PI3K Inhibitor (Pan)
PTEN Q110* PI3K Inhibitor (Pan)
PTEN G143fs PI3K Inhibitor (Pan)
PTEN E114* PI3K Inhibitor (Pan)
PTEN W274fs PI3K Inhibitor (Pan)
PTEN K163fs PI3K Inhibitor (Pan)
PTEN G230* PI3K Inhibitor (Pan)
PTEN N117fs PI3K Inhibitor (Pan)
PTEN N329fs PI3K Inhibitor (Pan)
PTEN Q219* PI3K Inhibitor (Pan)
PTEN M270fs PI3K Inhibitor (Pan)
PTEN D252Y PI3K Inhibitor (Pan)
PTEN G36R PI3K Inhibitor (Pan)
PTEN loss PI3K Inhibitor (Pan)
PTEN G293fs PI3K Inhibitor (Pan)
PTEN N63fs PI3K Inhibitor (Pan)
PTEN L23S PI3K Inhibitor (Pan)
PTEN I101S PI3K Inhibitor (Pan)
PTEN N48S PI3K Inhibitor (Pan)
PTEN G282* PI3K Inhibitor (Pan)
PTEN K237fs PI3K Inhibitor (Pan)
PTEN E284fs PI3K Inhibitor (Pan)
PTEN N48I PI3K Inhibitor (Pan)
PTEN C124N PI3K Inhibitor (Pan)
PTEN H123D PI3K Inhibitor (Pan)
PTEN E288fs PI3K Inhibitor (Pan)
PTEN I253N PI3K Inhibitor (Pan)
PTEN Y315* PI3K Inhibitor (Pan)
PTEN M199del PI3K Inhibitor (Pan)
PTEN L194fs PI3K Inhibitor (Pan)
PTEN R14G PI3K Inhibitor (Pan)
PTEN Y16D PI3K Inhibitor (Pan)
PTEN Y176* PI3K Inhibitor (Pan)
PTEN F21A PI3K Inhibitor (Pan)
PTEN I67K PI3K Inhibitor (Pan)
PTEN I28N PI3K Inhibitor (Pan)
PTEN D92A PI3K Inhibitor (Pan)
PTEN K13Q PI3K Inhibitor (Pan)
PTEN K128_R130del PI3K Inhibitor (Pan)
PTEN D24V PI3K Inhibitor (Pan)
PTEN Y178del PI3K Inhibitor (Pan)
PTEN T131P PI3K Inhibitor (Pan)
PTEN R234* PI3K Inhibitor (Pan)
PTEN R233* PI3K Inhibitor (Pan)
PTEN Q171* PI3K Inhibitor (Pan)
PTEN H118P PI3K Inhibitor (Pan)
PTEN L23F PI3K Inhibitor (Pan)
PTEN R130* PI3K Inhibitor (Pan)
PTEN Y88D PI3K Inhibitor (Pan)
PTEN V217G PI3K Inhibitor (Pan)
PTEN D92V PI3K Inhibitor (Pan)
PTEN I101T PI3K Inhibitor (Pan)
PTEN T319* PI3K Inhibitor (Pan)
PTEN E284* PI3K Inhibitor (Pan)
PTEN L318fs PI3K Inhibitor (Pan)
PTEN V343E PI3K Inhibitor (Pan)
PTEN S287* PI3K Inhibitor (Pan)
PTEN K102fs PI3K Inhibitor (Pan)
PTEN R189* PI3K Inhibitor (Pan)
PTEN R130fs PI3K Inhibitor (Pan)
PTEN W111* PI3K Inhibitor (Pan)
PTEN L193P PI3K Inhibitor (Pan)
PTEN I122fs PI3K Inhibitor (Pan)
PTEN R159L PI3K Inhibitor (Pan)
PTEN D252V PI3K Inhibitor (Pan)
PTEN L139* PI3K Inhibitor (Pan)
PTEN L247_P248del PI3K Inhibitor (Pan)
PTEN L325R PI3K Inhibitor (Pan)
PTEN H123Q PI3K Inhibitor (Pan)
PTEN V158fs PI3K Inhibitor (Pan)
PTEN T321* PI3K Inhibitor (Pan)
PTEN T321fs PI3K Inhibitor (Pan)
PTEN K62R PI3K Inhibitor (Pan)
PTEN Y68C PI3K Inhibitor (Pan)
PTEN C124W PI3K Inhibitor (Pan)
PTEN Q171P PI3K Inhibitor (Pan)
PTEN D24Y PI3K Inhibitor (Pan)
PTEN Y68H PI3K Inhibitor (Pan)
PTEN K342* PI3K Inhibitor (Pan)
PTEN G129V PI3K Inhibitor (Pan)
PTEN N276A PI3K Inhibitor (Pan)
PTEN I8Dfs*3 PI3K Inhibitor (Pan)
PTEN R130L PI3K Inhibitor (Pan)
PTEN K13E PI3K Inhibitor (Pan)
PTEN R15I PI3K Inhibitor (Pan)
PTEN N276K PI3K Inhibitor (Pan)
PTEN L247* PI3K Inhibitor (Pan)
PTEN C136W PI3K Inhibitor (Pan)
PTEN F56S PI3K Inhibitor (Pan)
PTEN F90S PI3K Inhibitor (Pan)
PTEN M35K PI3K Inhibitor (Pan)
PTEN H93L PI3K Inhibitor (Pan)
PTEN V217fs PI3K Inhibitor (Pan)
PTEN K144* PI3K Inhibitor (Pan)
PTEN K263* PI3K Inhibitor (Pan)
PTEN G165R PI3K Inhibitor (Pan)
PTEN L70P PI3K Inhibitor (Pan)
PTEN L193fs PI3K Inhibitor (Pan)
PTEN A34D PI3K Inhibitor (Pan)
PTEN H61P PI3K Inhibitor (Pan)
PTEN R142W PI3K Inhibitor (Pan)
PTEN Y178* PI3K Inhibitor (Pan)
PTEN R130A PI3K Inhibitor (Pan)
PTEN E299* PI3K Inhibitor (Pan)
PTEN V119G PI3K Inhibitor (Pan)
PTEN Y65* PI3K Inhibitor (Pan)
PTEN F278Lfs*12 PI3K Inhibitor (Pan)
PTEN L112R PI3K Inhibitor (Pan)
PTEN K183Ifs*15 PI3K Inhibitor (Pan)
PTEN L320S PI3K Inhibitor (Pan)
PTEN F56fs PI3K Inhibitor (Pan)
PTEN S294fs PI3K Inhibitor (Pan)
PTEN R41* PI3K Inhibitor (Pan)
PTEN V166Sfs*14 PI3K Inhibitor (Pan)
PTEN Q17* PI3K Inhibitor (Pan)
PTEN R130K PI3K Inhibitor (Pan)
PTEN R159S PI3K Inhibitor (Pan)
PTEN L345Q PI3K Inhibitor (Pan)
PTEN G251C PI3K Inhibitor (Pan)
PTEN C124G PI3K Inhibitor (Pan)
PTEN Y138L PI3K Inhibitor (Pan)
PTEN K221* PI3K Inhibitor (Pan)
PTEN A126D PI3K Inhibitor (Pan)
PTEN R335L PI3K Inhibitor (Pan)
PTEN A121P PI3K Inhibitor (Pan)
PTEN Y174* PI3K Inhibitor (Pan)
PTEN A39P PI3K Inhibitor (Pan)
PTEN I101N PI3K Inhibitor (Pan)
PTEN R335* PI3K Inhibitor (Pan)
PTEN Y27N PI3K Inhibitor (Pan)
PTEN F241fs PI3K Inhibitor (Pan)
PTEN N184Efs*16 PI3K Inhibitor (Pan)
PTEN L181P PI3K Inhibitor (Pan)
PTEN K66fs PI3K Inhibitor (Pan)
PTEN E157G PI3K Inhibitor (Pan)
PTEN V217D PI3K Inhibitor (Pan)
PTEN Y27fs PI3K Inhibitor (Pan)
PTEN inact mut PI3K Inhibitor (Pan)
PTEN K128E PI3K Inhibitor (Pan)
PTEN Y336* PI3K Inhibitor (Pan)
PTEN D107G PI3K Inhibitor (Pan)
PTEN K125E PI3K Inhibitor (Pan)
PTEN Y155H PI3K Inhibitor (Pan)
PTEN D331Tfs*13 PI3K Inhibitor (Pan)
PTEN Y155fs PI3K Inhibitor (Pan)
PTEN G156V PI3K Inhibitor (Pan)
PTEN Q171K PI3K Inhibitor (Pan)
PTEN S10del PI3K Inhibitor (Pan)
PTEN G129* PI3K Inhibitor (Pan)
PTEN Y16fs PI3K Inhibitor (Pan)
PTEN D326* PI3K Inhibitor (Pan)
PTEN A126S PI3K Inhibitor (Pan)
PTEN T167N PI3K Inhibitor (Pan)
PTEN V275G PI3K Inhibitor (Pan)
PTEN G293* PI3K Inhibitor (Pan)
PTEN Y27C PI3K Inhibitor (Pan)
PTEN K125N PI3K Inhibitor (Pan)
PTEN K267fs PI3K Inhibitor (Pan)
PTEN L108H PI3K Inhibitor (Pan)
PTEN P95S PI3K Inhibitor (Pan)
PTEN G132S PI3K Inhibitor (Pan)
PTEN M264T PI3K Inhibitor (Pan)
PTEN K125L PI3K Inhibitor (Pan)
PTEN G156W PI3K Inhibitor (Pan)
PTEN del PI3K Inhibitor (Pan)
PTEN Y225* PI3K Inhibitor (Pan)
PTEN N12T PI3K Inhibitor (Pan)
PTEN I33S PI3K Inhibitor (Pan)
PTEN M205I PI3K Inhibitor (Pan)
PTEN D109fs PI3K Inhibitor (Pan)
PTEN D326H PI3K Inhibitor (Pan)
PTEN T382S PI3K Inhibitor (Pan)
PTEN T131N PI3K Inhibitor (Pan)
PTEN E106* PI3K Inhibitor (Pan)
PTEN H123L PI3K Inhibitor (Pan)
PTEN T160del PI3K Inhibitor (Pan)
PTEN L320* PI3K Inhibitor (Pan)
PTEN Q245P PI3K Inhibitor (Pan)
PTEN G132V PI3K Inhibitor (Pan)
PTEN L108P PI3K Inhibitor (Pan)
PTEN C136R PI3K Inhibitor (Pan)
PTEN H93Y PI3K Inhibitor (Pan)
PTEN E288* PI3K Inhibitor (Pan)
PTEN Y177C PI3K Inhibitor (Pan)
PTEN C211* PI3K Inhibitor (Pan)
PTEN D326Y PI3K Inhibitor (Pan)
PTEN D24N PI3K Inhibitor (Pan)
PTEN D116fs PI3K Inhibitor (Pan)
PTEN Y76fs PI3K Inhibitor (Pan)
PTEN G36E PI3K Inhibitor (Pan)
PTEN K6del PI3K Inhibitor (Pan)
PTEN L108R PI3K Inhibitor (Pan)
PTEN T131fs PI3K Inhibitor (Pan)
PTEN K6E PI3K Inhibitor (Pan)
PTEN negative PI3K Inhibitor (Pan)
PTEN H93P PI3K Inhibitor (Pan)
PTEN Y188del PI3K Inhibitor (Pan)
PTEN K125* PI3K Inhibitor (Pan)
PTEN H61D PI3K Inhibitor (Pan)
PTEN Y68fs PI3K Inhibitor (Pan)
PTEN D107V PI3K Inhibitor (Pan)
PTEN M264R PI3K Inhibitor (Pan)
PTEN Q87* PI3K Inhibitor (Pan)
PTEN F154L PI3K Inhibitor (Pan)
PTEN S385* PI3K Inhibitor (Pan)
PTEN E150* PI3K Inhibitor (Pan)
PTEN E43fs PI3K Inhibitor (Pan)
PTEN V255A PI3K Inhibitor (Pan)
PTEN D326N PI3K Inhibitor (Pan)
PTEN A34P PI3K Inhibitor (Pan)
PTEN K266* PI3K Inhibitor (Pan)
PTEN V290fs PI3K Inhibitor (Pan)
PTEN V166G PI3K Inhibitor (Pan)
PTEN Q298* PI3K Inhibitor (Pan)
PTEN R159F PI3K Inhibitor (Pan)
PTEN R74Dfs*25 PI3K Inhibitor (Pan)
PTEN V290* PI3K Inhibitor (Pan)
PTEN T131I PI3K Inhibitor (Pan)
PTEN I253* PI3K Inhibitor (Pan)
PTEN K260* PI3K Inhibitor (Pan)
PTEN V166E PI3K Inhibitor (Pan)
PTEN K6* PI3K Inhibitor (Pan)
PTEN V54del PI3K Inhibitor (Pan)
PTEN Y174D PI3K Inhibitor (Pan)
PTEN G132del PI3K Inhibitor (Pan)
PTEN L265fs PI3K Inhibitor (Pan)
PTEN R14fs PI3K Inhibitor (Pan)
PTEN S229* PI3K Inhibitor (Pan)
PTEN K254Rfs*42 PI3K Inhibitor (Pan)
PTEN L70fs PI3K Inhibitor (Pan)
PTEN K269* PI3K Inhibitor (Pan)
PTEN N276T PI3K Inhibitor (Pan)
PTEN K128T PI3K Inhibitor (Pan)
PTEN C136Y PI3K Inhibitor (Pan)
PTEN P96Q PI3K Inhibitor (Pan)
PTEN V175E PI3K Inhibitor (Pan)
PTEN Y16* PI3K Inhibitor (Pan)
PTEN C124L PI3K Inhibitor (Pan)
PTEN L140* PI3K Inhibitor (Pan)
PTEN C218* PI3K Inhibitor (Pan)
PTEN H272P PI3K Inhibitor (Pan)
PTEN H93D PI3K Inhibitor (Pan)
PTEN N292fs PI3K Inhibitor (Pan)
PTEN D162del PI3K Inhibitor (Pan)
PTEN A126V PI3K Inhibitor (Pan)
PTEN M198R PI3K Inhibitor (Pan)
PTEN W111fs PI3K Inhibitor (Pan)
PTEN Q261* PI3K Inhibitor (Pan)
PTEN P96R PI3K Inhibitor (Pan)
PTEN D324del PI3K Inhibitor (Pan)
PTEN H118fs PI3K Inhibitor (Pan)
PTEN C105F PI3K Inhibitor (Pan)
PTEN E235* PI3K Inhibitor (Pan)
PTEN F56C PI3K Inhibitor (Pan)
PTEN K13* PI3K Inhibitor (Pan)
PTEN G132C PI3K Inhibitor (Pan)
PTEN L57S PI3K Inhibitor (Pan)
PTEN D24G PI3K Inhibitor (Pan)
PTEN S59P PI3K Inhibitor (Pan)
PTEN R55fs PI3K Inhibitor (Pan)
PTEN P246fs PI3K Inhibitor (Pan)
PTEN H61R PI3K Inhibitor (Pan)
PTEN Q171E PI3K Inhibitor (Pan)
PTEN L70V PI3K Inhibitor (Pan)
PTEN T348I PI3K Inhibitor (Pan)
PTEN L140F PI3K Inhibitor (Pan)
PTEN T277del PI3K Inhibitor (Pan)
PTEN T232A PI3K Inhibitor (Pan)
PTEN R142P PI3K Inhibitor (Pan)
PTEN V275* PI3K Inhibitor (Pan)
PTEN Y177S PI3K Inhibitor (Pan)
PTEN H123Y PI3K Inhibitor (Pan)
PTEN C124F PI3K Inhibitor (Pan)
PTEN Y76* PI3K Inhibitor (Pan)
PTEN D92G PI3K Inhibitor (Pan)
PTEN T277N PI3K Inhibitor (Pan)
PTEN S59* PI3K Inhibitor (Pan)
PTEN K125M PI3K Inhibitor (Pan)
PTEN F337fs PI3K Inhibitor (Pan)
PTEN D92E PI3K Inhibitor (Pan)
PTEN F257L PI3K Inhibitor (Pan)
PTEN V317fs PI3K Inhibitor (Pan)
PTEN V290Sfs*8 PI3K Inhibitor (Pan)
PTEN P248fs PI3K Inhibitor (Pan)
PTEN G129R PI3K Inhibitor (Pan)
PTEN G129E PI3K Inhibitor (Pan)
PTEN T131L PI3K Inhibitor (Pan)
PTEN C105Y PI3K Inhibitor (Pan)
PTEN A72fs PI3K Inhibitor (Pan)
PTEN Y65D PI3K Inhibitor (Pan)
PTEN G127R PI3K Inhibitor (Pan)
PTEN L182P PI3K Inhibitor (Pan)
PTEN Y27S PI3K Inhibitor (Pan)
PTEN R130P PI3K Inhibitor (Pan)
PTEN I122S PI3K Inhibitor (Pan)
PTEN N48K PI3K Inhibitor (Pan)
PTEN E307* PI3K Inhibitor (Pan)
PTEN L70R PI3K Inhibitor (Pan)
PTEN E73K PI3K Inhibitor (Pan)
PTEN I101F PI3K Inhibitor (Pan)
PTEN T167A PI3K Inhibitor (Pan)
PTEN D162Y PI3K Inhibitor (Pan)
PTEN F241S PI3K Inhibitor (Pan)
PTEN R173H PI3K Inhibitor (Pan)
PTEN Y177* PI3K Inhibitor (Pan)
PTEN Q171R PI3K Inhibitor (Pan)
PTEN D268Gfs*30 PI3K Inhibitor (Pan)
PTEN C136F PI3K Inhibitor (Pan)
PTEN M134T PI3K Inhibitor (Pan)
PTEN D92Y PI3K Inhibitor (Pan)
PTEN C71W PI3K Inhibitor (Pan)
PTEN Y188* PI3K Inhibitor (Pan)
PTEN L42R PI3K Inhibitor (Pan)
PTEN N323Kfs*2 PI3K Inhibitor (Pan)
PTEN K289Nfs*8 PI3K Inhibitor (Pan)
PTEN G20E PI3K Inhibitor (Pan)
PTEN Y176del PI3K Inhibitor (Pan)
PTEN C83* PI3K Inhibitor (Pan)
PTEN G165E PI3K Inhibitor (Pan)
PTEN V45del PI3K Inhibitor (Pan)
PTEN L23V PI3K Inhibitor (Pan)
PTEN K330* PI3K Inhibitor (Pan)
PTEN M35V PI3K Inhibitor (Pan)
PTEN K147* PI3K Inhibitor (Pan)
PTEN F145* PI3K Inhibitor (Pan)
PTEN Y46* PI3K Inhibitor (Pan)
PTEN G251D PI3K Inhibitor (Pan)
PTEN A151P PI3K Inhibitor (Pan)
PTEN R130S PI3K Inhibitor (Pan)
PTEN M198K PI3K Inhibitor (Pan)
PTEN T319del PI3K Inhibitor (Pan)
PTEN Q149* PI3K Inhibitor (Pan)
PTEN C124R PI3K Inhibitor (Pan)
PTEN M35R PI3K Inhibitor (Pan)
PTEN I33N PI3K Inhibitor (Pan)
PTEN L152P PI3K Inhibitor (Pan)
PTEN P38L PI3K Inhibitor (Pan)
PTEN W111R PI3K Inhibitor (Pan)
PTEN P38R PI3K Inhibitor (Pan)
PTEN V249E PI3K Inhibitor (Pan)
PTEN H93Q PI3K Inhibitor (Pan)
PTEN K254* PI3K Inhibitor (Pan)
PTEN H61L PI3K Inhibitor (Pan)
PTEN C105G PI3K Inhibitor (Pan)
PTEN V53E PI3K Inhibitor (Pan)
PTEN Y68D PI3K Inhibitor (Pan)
PTEN K254fs PI3K Inhibitor (Pan)
PTEN Q214* PI3K Inhibitor (Pan)
PTEN E314* PI3K Inhibitor (Pan)
PTEN G36* PI3K Inhibitor (Pan)
PTEN M134del PI3K Inhibitor (Pan)
PTEN S302Afs*5 PI3K Inhibitor (Pan)
PTEN S10N PI3K Inhibitor (Pan)
PTEN N94I PI3K Inhibitor (Pan)
PTEN G127N PI3K Inhibitor (Pan)
PTEN R173fs PI3K Inhibitor (Pan)
PTEN C71Y PI3K Inhibitor (Pan)
PTEN L247Sfs*6 PI3K Inhibitor (Pan)
PTEN R173C PI3K Inhibitor (Pan)
PTEN T131A PI3K Inhibitor (Pan)
PTEN Y88* PI3K Inhibitor (Pan)
PTEN I122L PI3K Inhibitor (Pan)
PTEN D107Y PI3K Inhibitor (Pan)
PTEN P95Q PI3K Inhibitor (Pan)
PTEN D109* PI3K Inhibitor (Pan)
PTEN E99* PI3K Inhibitor (Pan)
PTEN W111G PI3K Inhibitor (Pan)
PTEN Y46H PI3K Inhibitor (Pan)
PTEN A121E PI3K Inhibitor (Pan)
PTEN Y155N PI3K Inhibitor (Pan)
PTEN D24H PI3K Inhibitor (Pan)
PTEN D24del PI3K Inhibitor (Pan)
PTEN D92H PI3K Inhibitor (Pan)
PTEN E256* PI3K Inhibitor (Pan)
PTEN E43* PI3K Inhibitor (Pan)
PTEN R159I PI3K Inhibitor (Pan)
PTEN V119del PI3K Inhibitor (Pan)
PTEN V119fs PI3K Inhibitor (Pan)
PTEN R130G PI3K Inhibitor (Pan)
PTEN D77* PI3K Inhibitor (Pan)
PTEN M134I PI3K Inhibitor (Pan)
PTEN E291Gfs*7 PI3K Inhibitor (Pan)
PTEN F347L PI3K Inhibitor (Pan)
PTEN N340fs PI3K Inhibitor (Pan)
PTEN C105W PI3K Inhibitor (Pan)
PTEN D252G PI3K Inhibitor (Pan)
PTEN Q17del PI3K Inhibitor (Pan)
PTEN R15K PI3K Inhibitor (Pan)
PTEN Q17Rfs*26 PI3K Inhibitor (Pan)
PTEN T167P PI3K Inhibitor (Pan)
PTEN L112P PI3K Inhibitor (Pan)
PTEN G165* PI3K Inhibitor (Pan)
PTEN I135R PI3K Inhibitor (Pan)
PTEN V133I PI3K Inhibitor (Pan)
PTEN P95R PI3K Inhibitor (Pan)
PTEN S227F PI3K Inhibitor (Pan)
PTEN G44D PI3K Inhibitor (Pan)
PTEN L146* PI3K Inhibitor (Pan)
PTEN K128Q PI3K Inhibitor (Pan)
PTEN E91* PI3K Inhibitor (Pan)
PTEN C211W PI3K Inhibitor (Pan)
PTEN F271S PI3K Inhibitor (Pan)
PTEN K322E PI3K Inhibitor (Pan)
PTEN R15S PI3K Inhibitor (Pan)
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA R108H PTEN mut endometrial cancer sensitive Dactolisib Preclinical Actionable In a preclinical study, BEZ235 inhibited proliferation of endometrial cancer cells harboring PIK3CA R108H and PTEN mutations in culture (PMID: 22662154). 22662154
PTEN mutant endometrial cancer sensitive Dactolisib Preclinical Actionable In a preclinical study, BEZ235 decreased growth of endometrial cancer cells harboring a PTEN nonsense mutation in culture and in xenograft models (PMID: 22662154). 22662154
PIK3CA E365K PTEN mut endocervical carcinoma sensitive Dactolisib Preclinical Actionable In a preclinical study, BEZ235 inhibited proliferation of endometrial cancer cells harboring PIK3CA E365K and PTEN mutations in culture (PMID: 22662154). 22662154
PIK3CA R38C PTEN mut endometrial cancer sensitive Dactolisib Preclinical Actionable In a preclinical study, BEZ235 decreased growth of endometrial cancer cells harboring PIK3CA R38C and PTEN mutations in culture and in xenograft models (PMID: 22662154). 22662154
PIK3CA E365K PTEN mut endometrial cancer sensitive Dactolisib Preclinical Actionable In a preclinical study, BEZ235 inhibited proliferation of endometrial cancer cells harboring PIK3CA E365K and PTEN mutations in culture (PMID: 22662154). 22662154
PIK3CA R88Q PTEN mut endometrial cancer sensitive Everolimus Preclinical Actionable In a preclinical study, Afinitor (everolimus) inhibited proliferation of endometrial cancer cells harboring PIK3CA R88Q and PTEN mutations in culture (PMID: 22662154). 22662154
PTEN mutant endometrial cancer sensitive Everolimus Preclinical - Cell line xenograft Actionable In a preclinical study, Afinitor (everolimus) inhibited growth of endometrial cancer cells harboring a PTEN nonsense mutation in culture and in xenograft models (PMID: 22662154). 22662154
PIK3CA R88Q PTEN mut endometrial cancer sensitive Dactolisib Preclinical Actionable In a preclinical study, BEZ235 inhibited proliferation of endometrial cancer cells harboring PIK3CA R88Q and PTEN mutations in culture (PMID: 22662154). 22662154