Therapy Detail
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| Therapy Name | Capecitabine + Oxaliplatin + Zanidatamab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Capecitabine | Xeloda | R340 | Chemotherapy - Antimetabolite 14 | Xeloda (capecitabine) is an antimetabolite that when activated to 5-FU ultimately inhibits DNA synthesis and cell division (NCI Drug Dictionary). |
| Oxaliplatin | Eloxatin | Diaminocyclohexane Oxalatoplatinum | Chemotherapy - Platinum 7 | Eloxatin (oxaliplatin) is comprised of a platinum complex, which causes DNA-platinum cross-links, inhibition of DNA replication and transcription, and cell toxicity, and is FDA approved for colorectal cancer (FDA.gov). |
| Zanidatamab | Ziihera | ZW-25|ZW25|Zanidatamab-hrii | HER2 (ERBB2) Antibody 77 | Ziihera (zanidatamab) is a bispecific antibody targeting ERBB2 (HER2), which induces anti-tumor immune response against Erbb2 (Her2)-expressing tumors (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 255P, PMID: 32054397). Ziihera (zanidatamab) is FDA-approved for use in patients with unresectable or metastatic ERBB2 (HER2)-positive (IHC 3+) biliary tract cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03929666 | Phase II | Cisplatin + Gemcitabine Cisplatin + Fluorouracil + Zanidatamab Capecitabine + Oxaliplatin + Zanidatamab Fluorouracil + Leucovorin + Oxaliplatin + Zanidatamab Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + Zanidatamab | A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer | Active, not recruiting | USA | CAN | 2 |
| NCT05152147 | Phase III | Capecitabine + Oxaliplatin + Trastuzumab Capecitabine + Oxaliplatin + Zanidatamab Cisplatin + Fluorouracil + Trastuzumab Cisplatin + Fluorouracil + Zanidatamab Cisplatin + Fluorouracil + Tislelizumab + Zanidatamab Capecitabine + Oxaliplatin + Tislelizumab + Zanidatamab | A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers (HERIZON-GEA-01) | Active, not recruiting | TUR | ROU | POL | NLD | ITA | IRL | GRC | GBR | FRA | EST | ESP | DEU | CAN | BRA | BEL | AUS | ARG | 16 |
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