Therapy Detail
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| Therapy Name | Cisplatin + Fluorouracil + Zanidatamab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cisplatin | Platinol | CDDP | Chemotherapy - Platinum 7 | Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary). |
| Fluorouracil | Adrucil | 5-FU|5-Fluorouracil | Chemotherapy - Antimetabolite 14 | Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent, which interferes with DNA and RNA synthesis thereby preventing cancer cell growth and is FDA approved for colorectal, breast, stomach, and pancreatic cancer (FDA.gov). |
| Zanidatamab | Ziihera | ZW-25|ZW25|Zanidatamab-hrii | HER2 (ERBB2) Antibody 76 | Ziihera (zanidatamab) is a bispecific antibody targeting ERBB2 (HER2), which induces anti-tumor immune response against Erbb2 (Her2)-expressing tumors (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 255P, PMID: 32054397). Ziihera (zanidatamab) is FDA-approved for use in patients with unresectable or metastatic ERBB2 (HER2)-positive (IHC 3+) biliary tract cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05152147 | Phase III | Capecitabine + Oxaliplatin + Trastuzumab Capecitabine + Oxaliplatin + Zanidatamab Cisplatin + Fluorouracil + Trastuzumab Cisplatin + Fluorouracil + Zanidatamab Cisplatin + Fluorouracil + Tislelizumab + Zanidatamab Capecitabine + Oxaliplatin + Tislelizumab + Zanidatamab | A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers (HERIZON-GEA-01) | Recruiting | TUR | ROU | POL | NLD | ITA | IRL | GRC | GBR | FRA | EST | ESP | DEU | CZE | CAN | BRA | BEL | AUS | ARG | 16 |
| NCT03929666 | Phase II | Cisplatin + Gemcitabine Cisplatin + Fluorouracil + Zanidatamab Capecitabine + Oxaliplatin + Zanidatamab Fluorouracil + Leucovorin + Oxaliplatin + Zanidatamab Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + Zanidatamab | A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer | Active, not recruiting | USA | CAN | 2 |
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