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Therapy Name Cetrelimab
Synonyms
Therapy Description

Cetrelimab (JNJ-63723283) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28943093).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cetrelimab JNJ63723283|JNJ 63723283|JNJ-63723283 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 Cetrelimab (JNJ-63723283) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28943093).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 over exp lung non-small cell carcinoma predicted - sensitive Cetrelimab Phase Ib/II Actionable In a Phase I/II trial, Cetrelimab (JNJ-63723283) treatment demonstrated safety and resulted in an overall response rate (ORR) of 18.6% (38/204), clinical benefit rate (CBR) of 31.3% (64/204), median progression-free survival (mPFS) of 2.8 mo, and median overall survival (mOS) of 17.8 mo in patients with advanced solid tumors, with an ORR of 52.6% (10/19, all partial responses) and CBR of 73.7% (14/50) in non-small cell lung cancer patients with high CD274 (PD-L1) expression (PMID: 35298698; NCT02908906). 35298698
CD274 positive melanoma predicted - sensitive Cetrelimab Phase Ib/II Actionable In a Phase I/II trial, Cetrelimab (JNJ-63723283) treatment demonstrated safety, and resulted in an overall response rate (ORR) of 18.6% (38/204), clinical benefit rate (CBR) of 31.3% (64/204), median progression-free survival (mPFS) of 2.8 mo, and median overall survival (mOS) of 17.8 mo in advanced solid tumor patients, with an ORR of 50% (4/8, 1 complete and 3 partial responses), and CBR of 75% (6/8) in CD274 (PD-L1)-positive melanoma patients (PMID: 35298698; NCT02908906). 35298698

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02908906 Phase I Cetrelimab A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers Active, not recruiting USA | SWE | POL | GBR | ESP 2
NCT04919512 Phase II Cetrelimab + TAR-200 Cetrelimab A Study of TAR-200 in Combination With Cetrelimab and Cetrelimab Alone in Participants With Muscle-Invasive Urothelial Carcinoma of the Bladder (SunRISe-4) Active, not recruiting USA | NLD | ITA | ISR | GBR | FRA | ESP | DEU | BEL 1


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