Therapy Detail
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| Therapy Name | Cyclophosphamide + Vinorelbine |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cyclophosphamide | Cytoxan | CPM | Chemotherapy - Alkylating 18 | Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary). |
| Vinorelbine | Navelbine | Vinorelbin | Antimicrotubule Agent 14 | Navelbine (vinorelbine) is a tubulin binding alkaloid that inhibits tubulin polymerization, thus inhibiting spindle formation, leading to apoptosis (NCI Drug Dictionary). Navelbine (vinorelbine) is approved for use in NSCLC (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04145349 | Phase Ib/II | Cyclophosphamide + Vinorelbine Cyclophosphamide + Ramucirumab + Vinorelbine | CAMFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Desmoplastic Small Round Cell Tumor | Active, not recruiting | USA | ITA | GBR | ESP | DEU | AUS | 1 |
| NCT05999994 | Phase II | Docetaxel + Gemcitabine + Ramucirumab Cyclophosphamide + Ramucirumab + Vinorelbine Cyclophosphamide + Vinorelbine Irinotecan + Temozolomide Abemaciclib + Irinotecan + Temozolomide Docetaxel + Gemcitabine | A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer (CAMPFIRE) | Recruiting | USA | ITA | GBR | FRA | ESP | DEU | BEL | AUS | 1 |
| NCT04625907 | Phase Ib/II | Irinotecan + Temozolomide + Vincristine Sulfate Dactinomycin + Ifosfamide + Vincristine Sulfate Irinotecan + Regorafenib + Vincristine Sulfate Dactinomycin + Ifosfamide + Irinotecan + Vincristine Sulfate Dactinomycin + Doxorubicin + Ifosfamide + Vincristine Sulfate Cyclophosphamide + Vinorelbine | FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma (FaR-RMS) | Recruiting | SWE | SVN | SVK | NZL | NOR | NLD | ITA | ISR | IRL | GRC | GBR | FRA | ESP | DNK | CZE | CHE | BEL | AUT | AUS | 1 |
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