Therapy Detail
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| Therapy Name | Cisplatin + Pembrolizumab and berahyaluronidase alfa-pmph + Pemetrexed Disodium |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cisplatin | Platinol | CDDP | Chemotherapy - Platinum 7 | Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary). |
| Pembrolizumab and berahyaluronidase alfa-pmph | Keytruda Qlex | MK 3475A|MK3475A|MK-3475A | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 136 | Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) is a co-formulation of Keytruda (pembrolizumab) and berahyaluronidase alfa, which potentially enhances antitumor immune response (J Clin Oncol 2025 43: 16_suppl, TPS7090, NCI Drug Dictionary). Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) is FDA-approved for use in adult and pediatric (12 years and older) solid tumor indications approved for the intravenous formulation of Keytruda (Pembrolizumab) (FDA.gov). |
| Pemetrexed Disodium | Alimta | LY231514|Ciambra|pemetrexed | Chemotherapy - Antimetabolite 14 | Alimta (pemetrexed disodium) is an antifolate that inhibits thymidylate synthase (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05722015 | Phase III | Cisplatin + Pembrolizumab + Pemetrexed Disodium Carboplatin + Nab-paclitaxel + Pembrolizumab and berahyaluronidase alfa-pmph Carboplatin + Paclitaxel + Pembrolizumab Carboplatin + Nab-paclitaxel + Pembrolizumab Cisplatin + Pembrolizumab and berahyaluronidase alfa-pmph + Pemetrexed Disodium Carboplatin + Paclitaxel + Pembrolizumab and berahyaluronidase alfa-pmph | A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77) | Active, not recruiting | USA | TUR | ROU | POL | HUN | FRA | ESP | BRA | ARG | 7 |
| NCT07190248 | Phase III | Carboplatin + Pembrolizumab and berahyaluronidase alfa-pmph + Pemetrexed Disodium MK-1084 + Pembrolizumab and berahyaluronidase alfa-pmph Cisplatin + Pembrolizumab and berahyaluronidase alfa-pmph + Pemetrexed Disodium | A Clinical Study of MK-1084 and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) | Recruiting | USA | ROU | POL | ISR | HUN | GRC | FRA | ESP | AUT | AUS | ARG | 5 |
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