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Therapy Name MK-1084 + Pembrolizumab and berahyaluronidase alfa-pmph
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MK-1084 MK 1084|MK1084 KRAS G12C inhibitor 36 MK-1084 is a selective inhibitor of KRAS G12C, which inhibits downstream signaling, potentially resulting in decreased tumor cell proliferation, and antitumor activity (NCI Drug Dictionary, Ann Oncol 34 (2023): S466-S467).
Pembrolizumab and berahyaluronidase alfa-pmph Keytruda Qlex MK 3475A|MK3475A|MK-3475A Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 134 Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) is a co-formulation of Keytruda (pembrolizumab) and berahyaluronidase alfa, which potentially enhances antitumor immune response (J Clin Oncol 2025 43: 16_suppl, TPS7090, NCI Drug Dictionary). Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) is FDA-approved for use in adult and pediatric (12 years and older) solid tumor indications approved for the intravenous formulation of Keytruda (Pembrolizumab) (FDA.gov).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT07190248 Phase III Carboplatin + Pembrolizumab and berahyaluronidase alfa-pmph + Pemetrexed Disodium MK-1084 + Pembrolizumab and berahyaluronidase alfa-pmph Cisplatin + Pembrolizumab and berahyaluronidase alfa-pmph + Pemetrexed Disodium A Clinical Study of MK-1084 and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) Recruiting USA | ROU | ISR | HUN | ESP | AUS 4


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