Therapy Detail
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| Therapy Name | Mosunetuzumab-axgb + Zanubrutinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Mosunetuzumab-axgb | Lunsumio | RG7828|BTCT4465A|RO7030816|BTCT-4465A | CD20 Antibody 26 CD3 Antibody 119 | Lunsumio (mosunetuzumab-axgb) is a bispecific antibody targeting CD20 and CD3, which may result in killing of CD20-positive tumor cells (PMID: 25972002, PMID: 29351372). Lunsumio (mosunetuzumab-axgb) is FDA approved for use in adult patients with relapsed or refractory follicular lymphoma who have received two or more lines of systemic therapy (FDA.gov). |
| Zanubrutinib | Brukinsa | BGB-3111 | BTK inhibitor 38 | Brukinsa (zanubrutinib) inhibits Bruton tyrosine kinase (BTK), leading to decreased B-cell activation and reduced growth of BTK over-expressing cells (PMID: 31378456). Brukinsa (zanubrutinib) is FDA approved for use in patients with mantle cell lymphoma, Waldenstrom’s macroglobulinemia, and chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07052695 | Phase Ib/II | Mosunetuzumab-axgb + Pirtobrutinib Mosunetuzumab-axgb Mosunetuzumab-axgb + Zanubrutinib Ibrutinib + Mosunetuzumab-axgb Acalabrutinib + Mosunetuzumab-axgb | Mosunetuzumab for CLL MRD Clearance | Not yet recruiting | USA | 0 |
| NCT05389293 | Phase II | Mosunetuzumab-axgb Mosunetuzumab-axgb + Zanubrutinib | A Study of Mosunetuzumab Alone or With Zanubrutinib in People With Follicular Lymphoma | Recruiting | USA | 0 |
| NCT06492837 | Phase II | Mosunetuzumab-axgb + Zanubrutinib | Study With Mosunetuzumab and Zanubrutinib in R/R Follicular Lymphoma Patients (FIL_MOZART) | Recruiting | ITA | AUS | 0 |
| NCT06563505 | Phase II | Mosunetuzumab-axgb + Zanubrutinib | A Phase 2 Trial of Mosunetuzumab and Zanubrutinib for Patients With Relapsed/Refractory Marginal Zone Lymphoma | Recruiting | USA | 0 |
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