Therapy Detail
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| Therapy Name | Acalabrutinib + Mosunetuzumab-axgb |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Acalabrutinib | Calquence | ACP-196 | BTK inhibitor 38 | Calquence (acalabrutinib) selectively inhibits BTK, resulting in decreased B-cell receptor signaling, and potentially leading to decreased tumor cell proliferation (PMID: 27903679, PMID: 26957112). Calquence (acalabrutinib) is FDA approved for use in patients with mantle cell lymphoma, chronic lymphocytic leukemia or small lymphocytic lymphoma, and in combination with Treanda (bendamustine) and Rituxan (rituximab) in patients with untreated mantle cell lymphoma who are ineligible for autologous hematopoietic stem cell transplantation (FDA.gov). |
| Mosunetuzumab-axgb | Lunsumio | RG7828|BTCT4465A|RO7030816|BTCT-4465A | CD20 Antibody 26 CD3 Antibody 119 | Lunsumio (mosunetuzumab-axgb) is a bispecific antibody targeting CD20 and CD3, which may result in killing of CD20-positive tumor cells (PMID: 25972002, PMID: 29351372). Lunsumio (mosunetuzumab-axgb) is FDA approved for use in adult patients with relapsed or refractory follicular lymphoma who have received two or more lines of systemic therapy (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07052695 | Phase Ib/II | Mosunetuzumab-axgb + Pirtobrutinib Mosunetuzumab-axgb Mosunetuzumab-axgb + Zanubrutinib Ibrutinib + Mosunetuzumab-axgb Acalabrutinib + Mosunetuzumab-axgb | Mosunetuzumab for CLL MRD Clearance | Not yet recruiting | USA | 0 |
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