Therapy Detail
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| Therapy Name | Acalabrutinib + TNB-486 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Acalabrutinib | Calquence | ACP-196 | BTK inhibitor 38 | Calquence (acalabrutinib) selectively inhibits BTK, resulting in decreased B-cell receptor signaling, and potentially leading to decreased tumor cell proliferation (PMID: 27903679, PMID: 26957112). Calquence (acalabrutinib) is FDA approved for use in patients with mantle cell lymphoma, chronic lymphocytic leukemia or small lymphocytic lymphoma, and in combination with Treanda (bendamustine) and Rituxan (rituximab) in patients with untreated mantle cell lymphoma who are ineligible for autologous hematopoietic stem cell transplantation (FDA.gov). |
| TNB-486 | TNB486|TNB 486|AZD0486|AZD-0486|AZD 0486 | CD19 Antibody 21 CD3 Antibody 104 | TNB-486 is a bispecific T-cell redirecting antibody that binds to CD19 on tumor cells as well as CD3, and may lead to tumor cell killing and inhibition of tumor growth (Blood (2019) 134 (Supplement_1): 4070). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06564038 | Phase Ib/II | Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + TNB-486 + Vincristine Sulfate Acalabrutinib + TNB-486 TNB-486 | A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies (Soundtrack-E) | Recruiting | USA | GBR | FRA | ESP | DNK | DEU | CZE | AUS | 4 |
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