Therapy Detail
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| Therapy Name | Belzutifan + XL092 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Belzutifan | Welireg | PT2977|MK-6482|PT-2977 | HIF2A Inhibitor 6 | Welireg (belzutifan) is a hypoxia inducible factor-2alpha (EPAS1, HIF2A) inhibitor that suppresses expression of HIF2A target genes, resulting in tumor regression (Mol Cancer Ther 2018,17(1 Suppl):Abstract nr B140, PMID: 31282155). Welireg (belzutifan) is FDA-approved for use in patients with von Hippel-Lindau (VHL) disease-associated renal cell carcinoma, central nervous system hemangioblastomas, or pancreatic neuroendocrine tumors that require therapy, in patients with advanced renal cell carcinoma who have received anti-PD-1 or PD-L1 therapy and VEGF inhibitor, in adult and pediatric patients 12 years and older with pheochromocytoma or paraganglioma, and in combination with Keytruda (pembrolizumab) in adult patients with clear cell renal cell carcinoma (FDA.gov). |
| XL092 | XL-092|XL 092|Zanzalintinib | MET Inhibitor 59 VEGFR Inhibitor (Pan) 36 | XL092 is a receptor tyrosine kinase inhibitor that targets MET, AXL, VEGFR2, TYRO3, and MER, which potentially leads to decreased tumor cell proliferation and inhibition of tumor growth (PMID: 36399631). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07227402 | Phase III | Cabozantinib Belzutifan + XL092 | A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033) (LITESPARK-033) | Recruiting | USA | POL | ITA | IRL | HRV | GRC | FRA | ESP | DNK | DEU | CZE | BRA | BEL | AUT | AUS | ARG | 5 |
| NCT07049926 | Phase Ib/II | Belzutifan Belzutifan + XL092 | Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03) | Recruiting | USA | POL | ISR | GBR | FRA | ESP | 2 |
| NCT07489495 | Phase III | Belzutifan Belzutifan + XL092 | A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034) | Recruiting | POL | NLD | ITA | ISR | GRC | FRA | ESP | DNK | CZE | AUS | ARG | 1 |
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