Therapy Detail
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| Therapy Name | Epcoritamab-bysp + ONC-PluReceptor NK cells + Tafasitamab-cxix |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Epcoritamab-bysp | Epkinly | DuoBody-CD3xCD20|GEN 3013|GEN-3013|GEN3013|epcoritamab | CD20 Antibody 26 CD3 Antibody 120 | Epkinly (epcoritamab-bysp) is a bispecific antibody that targets CD3 and CD20, resulting in T-cell activation and redirection of T-cells to CD20-expressing tumor cells, which may lead to tumor cell cytotoxicity and inhibition of tumor growth (PMID: 31981978, PMID: 33602901). Epkinly (epcoritamab-bysp) is FDA-approved for use in patients with relapsed or refractory diffuse large B-cell lymphoma, high-grade B-cell lymphoma, and follicular lymphoma after two or more lines of systemic therapy and in combination with Revlimid (lenalidomide) and Rituxan (rituximab) in patients with relapsed/refractory follicular lymphoma (FDA.gov). |
| ONC-PluReceptor NK cells | ONC PluReceptor NK-cells | Limited information is available on ONC-PluReceptor NK cells, putative umbilical cord blood-derived natural killer (NK) cells transduced with CD3 complex and IL-15 (Dec 2025). | ||
| Tafasitamab-cxix | Monjuvi | MOR00208|XmAb5574|MOR-208|MOR208|Tafasitamab | CD19 Antibody 21 | Monjuvi (tafasitamab-cxix) is an CD19-targeted antibody with an engineered Fc region, which may result in an increased antibody-dependent cell-mediated cytotoxicity response against CD19-expressing tumor cells (PMID: 23277329, PMID: 32511983). Monjuvi (tafasitamab-cxix) is FDA approved for use in combination with Revlimid (lenalidomide) in patients with relapsed or refractory diffuse large B cell lymphoma, and in combination with Revlimid (lenalidomide) and Rituxan (rituximab) in patients with relapsed or refractory follicular lymphoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07283679 | Phase Ib/II | Epcoritamab-bysp + ONC-PluReceptor NK cells + Tafasitamab-cxix | Phase I/II Trial of ONC-PluReceptor NK Cells With Epcoritamab and Tafasitamab for Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma | Not yet recruiting | USA | 0 |
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