Therapy Detail
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| Therapy Name | Inobrodib + Lenalidomide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Inobrodib | CCS-1477|CCS 1477|CCS1477 | CBP/p300 inhibitor 13 | Inobrodib (CCS-1477) binds to and inhibits p300 (EP300) and CBP (CREBBP) and inhibits NRF2-dependent transcription, potentially resulting in increased anti-tumor immune response, increased cell cycle arrest, and inhibition of tumor growth (PMID: 33431496, PMID: 39266679, PMID: 40127850, PMID: 39885312). | |
| Lenalidomide | Revlimid | IMiD-1 | Revlimid (lenalidomide) is a thalidomide analog which regulates cytokine production and stimulates T cells and NK cells activity (PMID: 24328678). Revlimid (lenalidomide) is FDA approved for use in multiple myeloma, relapsed or refractory Mantle cell lymphoma, and in combination with a rituximab product in follicular lymphoma and marginal zone lymphoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04068597 | Phase Ib/II | Azacitidine + Inobrodib Azacitidine + Inobrodib + Venetoclax Dexamethasone + Inobrodib + Pomalidomide Dexamethasone + Inobrodib + Ixazomib Inobrodib Elranatamab-bcmm + Inobrodib Inobrodib + Teclistamab Daratumumab + Inobrodib + Lenalidomide Inobrodib + Lenalidomide Bortezomib + Dexamethasone + Inobrodib | Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies | Recruiting | USA | SWE | GBR | FRA | ESP | 0 |
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