Therapy Detail
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| Therapy Name | Inobrodib |
| Synonyms | |
| Therapy Description |
Inobrodib (CCS-1477) binds to and inhibits p300 (EP300) and CBP (CREBBP) and inhibits NRF2-dependent transcription, potentially resulting in increased anti-tumor immune response, increased cell cycle arrest, and inhibition of tumor growth (PMID: 33431496, PMID: 39266679, PMID: 40127850, PMID: 39885312). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Inobrodib | CCS-1477|CCS 1477|CCS1477 | CBP/p300 inhibitor 13 | Inobrodib (CCS-1477) binds to and inhibits p300 (EP300) and CBP (CREBBP) and inhibits NRF2-dependent transcription, potentially resulting in increased anti-tumor immune response, increased cell cycle arrest, and inhibition of tumor growth (PMID: 33431496, PMID: 39266679, PMID: 40127850, PMID: 39885312). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04068597 | Phase Ib/II | Inobrodib | Study to Evaluate CCS1477 in Haematological Malignancies | Recruiting | USA | GBR | ESP | 0 |
| NCT03568656 | Phase Ib/II | Atezolizumab + Inobrodib Inobrodib Inobrodib + Olaparib Darolutamide + Inobrodib Abiraterone + Inobrodib Enzalutamide + Inobrodib | Study to Evaluate CCS1477 in Advanced Tumours | Completed | USA | SWE | NLD | GBR | FRA | ESP | 0 |
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