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Therapy Name Azacitidine + Inobrodib
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Azacitidine Vidaza azacytidine|CC-486|5-azacytidine|5-AC|U-18496|Onureg DNMT inhibitor (Pan) 5 Vidaza (azacitidine) is a cytidine analog that incorporates into DNA and RNA and binds to DNA methyltransferases (DNMTs), resulting in DNMT degradation and decreased DNA methylation, and leading to increased tumor cell death (PMID: 28159832, PMID: 28067760). Vidaza (azacitidine) is FDA-approved for use in patients with some subtypes of myelodysplastic syndrome and Onureg (azacitidine) is FDA approved for use in continued treatment of acute myeloid leukemia(FDA.gov).
Inobrodib CCS-1477|CCS 1477|CCS1477 CBP/p300 inhibitor 13 Inobrodib (CCS-1477) binds to and inhibits p300 (EP300) and CBP (CREBBP) and inhibits NRF2-dependent transcription, potentially resulting in increased anti-tumor immune response, increased cell cycle arrest, and inhibition of tumor growth (PMID: 33431496, PMID: 39266679, PMID: 40127850, PMID: 39885312).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04068597 Phase Ib/II Azacitidine + Inobrodib Azacitidine + Inobrodib + Venetoclax Dexamethasone + Inobrodib + Pomalidomide Dexamethasone + Inobrodib + Ixazomib Inobrodib Elranatamab-bcmm + Inobrodib Inobrodib + Teclistamab Daratumumab + Inobrodib + Lenalidomide Inobrodib + Lenalidomide Bortezomib + Dexamethasone + Inobrodib Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies Recruiting USA | SWE | GBR | FRA | ESP 0


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