Therapy Detail
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| Therapy Name | Carboplatin + Daraxonrasib + Ivonescimab + Pemetrexed Disodium |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| Daraxonrasib | RMC 6236|RMC6236|RMC-6236 | RAS Inhibitor (Pan) 14 | Daraxonrasib (RMC-6236) forms a binary complex with CypA, which prevents GTP-bound RAS from interacting with downstream effectors, potentially leading to anti-tumor activity (Cancer Res 2022;82(12_Suppl): Abstract nr 3597, PMID: 38593348). | |
| Ivonescimab | AK112|AK 112|AK-112|SMT112|SMT 112|SMT-112 | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 136 VEGFA Antibody 5 | Ivonescimab is a bispecific antibody that binds PD-1 and VEGFA, potentially resulting in antitumor activity (PMID: 37593227). | |
| Pemetrexed Disodium | Alimta | LY231514|Ciambra|pemetrexed | Chemotherapy - Antimetabolite 14 | Alimta (pemetrexed disodium) is an antifolate that inhibits thymidylate synthase (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07397338 | Phase Ib/II | Ivonescimab + RMC-9805 Cetuximab + Ivonescimab + RMC-9805 Ivonescimab + RMC-6291 Daraxonrasib + Ivonescimab + RMC-6291 Carboplatin + Ivonescimab + Pemetrexed Disodium + RMC-6291 Cisplatin + Ivonescimab + Pemetrexed Disodium + RMC-6291 Daraxonrasib + Ivonescimab Carboplatin + Daraxonrasib + Ivonescimab + Pemetrexed Disodium Cisplatin + Daraxonrasib + Ivonescimab + Pemetrexed Disodium | Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors | Recruiting | USA | 0 |
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