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Therapy Name Tislelizumab + Zanidatamab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tislelizumab Tevimbra BGB-A317|tislelizumab-jsgr Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 137 Tevimbra (tislelizumab) is a human monoclonal antibody that targets PD-1 (PDCD1), thereby blocking the binding of PD-L1 (CD274) and potentially resulting in activation of a T-cell immune response against tumor cells (PMID: 32769013, PMID: 32561638, PMID: 32540858). Tevimbra (tislelizumab) is FDA-approved for use in patients with unresectable or metastatic esophageal squamous cell carcinoma (FDA.gov).
Zanidatamab Ziihera ZW-25|ZW25|Zanidatamab-hrii HER2 (ERBB2) Antibody 80 Ziihera (zanidatamab) is a bispecific antibody targeting ERBB2 (HER2), which induces anti-tumor immune response against Erbb2 (Her2)-expressing tumors (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 255P, PMID: 32054397). Ziihera (zanidatamab) is FDA-approved for use in patients with unresectable or metastatic ERBB2 (HER2)-positive (IHC 3+) biliary tract cancer (FDA.gov).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04164199 Phase III Lenvatinib + Tislelizumab Sitravatinib LBL-007 + Tislelizumab Tislelizumab + Zanidatamab Pamiparib + Tislelizumab Fruquintinib + Tislelizumab BGB-A425 + Tislelizumab BGBA1217 + Tislelizumab BGB-15025 BGB-A425 + LBL-007 + Tislelizumab Tislelizumab BGB-15025 + Tislelizumab BGB-A445 + Tislelizumab Sitravatinib + Tislelizumab Pamiparib + Temozolomide Zanidatamab BAT1706 + Tislelizumab BAT1706 Pamiparib Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies Active, not recruiting USA | TUR | POL | NZL | ITA | FRA | AUS 6


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