Therapy Detail
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| Therapy Name | Rimiducid + Trastuzumab deruxtecan + TROP2-CAR/IL15-transduced CBNK cells |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Rimiducid | AP1903|AP-1903|AP 1903 | Rimiducid (AP1903) is a small molecule that selectively binds to mutant FKBP12 and induces dimerization and downstream signaling, which can be used to activate a safety switch in transplanted cells to potentially induce apoptosis and prevent graft-versus-host disease (PMID: 9724721, PMID: 22047558, PMID: 28697888). | ||
| TROP2-CAR/IL15-transduced CBNK cells | TROP2-CAR-NK cells|TROP2-CAR-engineered IL15-transduced Cord Blood-derived NKs | TROP2-CAR/IL15-transduced CBNK cells are cord blood-derived natural killer (NK) cells engineered to express IL15 and a chimeric antigen receptor (CAR) that targets TROP2, which potentially induce cytotoxicity against tumor cells expressing TROP2 (NCI Drug Dictionary). | ||
| Trastuzumab deruxtecan | Enhertu | DS-8201|DS8201a|T-DXd|DS-8201|fam-trastuzumab deruxtecan-nxki|DS-8201a | HER2 (ERBB2) Antibody 80 HER2 (ERBB2) Antibody-Drug Conjugate 36 | Enhertu (trastuzumab deruxtecan) is an antibody-drug conjugate (ADC) comprising an anti-ERBB2 (HER2) antibody linked to a derivative of the topoisomerase inhibitor DX-8951, which delivers the cytotoxic agent to ERBB2 (HER2)-expressing tumor cells, potentially resulting in decreased growth of tumors, including tumors with low ERBB2 (HER2) expression (PMID: 27026201). Enhertu (fam-trastuzumab deruxtecan-nxki) is FDA approved for use in patients with ERBB2 (HER2)-positive breast cancer who have received two or more anti-HER2 therapies previously, in patients with ERBB2 (HER2)-low (IHC 1+ or IHC 2+/ISH -) breast cancer received prior chemotherapy, in patients with ERBB2 (HER2)-low or untra-low (IHC 0 with membrane staining) hormone receptor-positive breast cancer who had received endocrine therapy, in patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal (GEJ) adenocarcinoma who have received prior trastuzumab-based therapy, in patients with non-small cell lung cancer harboring ERBB2 (HER2) activating mutations who have received prior systemic therapy, in patients with ERBB2 (HER2)-positive (IHC 3+) solid tumors who have received prior systemic therapy, and in combination with Perjeta (pertuzumab) in patients with ERBB2 (HER2)-positive breast cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07553390 | Phase I | Rimiducid + Trastuzumab deruxtecan + TROP2-CAR/IL15-transduced CBNK cells | Phase 1b Study Of TRICK-NK In Combination With T-Dxd In Treatment-Refractory Breast Cancers | Not yet recruiting | USA | 0 |
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