Therapy Detail
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| Therapy Name | CPI-0610 |
| Synonyms | |
| Therapy Description |
CPI-0610 is a small molecule that binds to BET bromodomains and inhibits interaction with acetylated histones, resulting in regulation of BET-dependent gene expression and anti-tumor effects (PMID: 26815195, PMID: 31729905). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CPI-0610 | CPI0610|pelabresib | BET Inhibitor (Pan) 32 | CPI-0610 is a small molecule that binds to BET bromodomains and inhibits interaction with acetylated histones, resulting in regulation of BET-dependent gene expression and anti-tumor effects (PMID: 26815195, PMID: 31729905). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02157636 | Phase I | CPI-0610 | A Phase 1 Study Evaluating CPI-0610 in Patients With Previously Treated Multiple Myeloma | Completed | 0 | |
| NCT02158858 | Phase Ib/II | CPI-0610 + Ruxolitinib CPI-0610 | A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis | Completed | USA | POL | NLD | ITA | GBR | FRA | DEU | CAN | BEL | 0 |
| NCT01949883 | Phase I | CPI-0610 | A Phase 1 Study Evaluating CPI-0610 in Patients With Progressive Lymphoma | Completed | 0 | |
| NCT02986919 | Phase II | CPI-0610 | Study of CPI-0610 in Patients With Malignant Peripheral Nerve Sheath Tumors | Withdrawn | USA | 0 |
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