Therapy Detail
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| Therapy Name | Pelabresib |
| Synonyms | |
| Therapy Description |
Pelabresib (CPI-0610) is a small molecule that binds to BET bromodomains and inhibits interaction with acetylated histones, potentially resulting in regulation of BET-dependent gene expression and antitumor activity (PMID: 26815195, PMID: 31729905). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Pelabresib | CPI0610|CPI-0610|CPI0610 | BET Inhibitor (Pan) 33 | Pelabresib (CPI-0610) is a small molecule that binds to BET bromodomains and inhibits interaction with acetylated histones, potentially resulting in regulation of BET-dependent gene expression and antitumor activity (PMID: 26815195, PMID: 31729905). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02986919 | Phase II | Pelabresib | Study of CPI-0610 in Patients With Malignant Peripheral Nerve Sheath Tumors | Withdrawn | USA | 0 |
| NCT01949883 | Phase I | Pelabresib | A Phase 1 Study Evaluating CPI-0610 in Patients With Progressive Lymphoma | Completed | 0 | |
| NCT02158858 | Phase Ib/II | Pelabresib + Ruxolitinib Pelabresib | A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis | Completed | USA | POL | NLD | ITA | GBR | FRA | DEU | CAN | BEL | 0 |
| NCT02157636 | Phase I | Pelabresib | A Phase 1 Study Evaluating CPI-0610 in Patients With Previously Treated Multiple Myeloma | Completed | 0 |
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