Therapy Detail
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| Therapy Name | Pelabresib + Ruxolitinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Pelabresib | CPI0610|CPI-0610|CPI0610 | BET Inhibitor (Pan) 33 | Pelabresib (CPI-0610) is a small molecule that binds to BET bromodomains and inhibits interaction with acetylated histones, potentially resulting in regulation of BET-dependent gene expression and antitumor activity (PMID: 26815195, PMID: 31729905). | |
| Ruxolitinib | Jakafi | INCB 18424|INCB018424|INCB18424 | JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15 | Jakafi (ruxolitinib) is an inhibitor of protein tyrosine kinases JAK1 and JAK2, thus resulting in reduced inflammation and reduced proliferation (PMID: 22474318). Jakafi (ruxolitinib) is FDA approved to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis (FDA.gov) |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02158858 | Phase Ib/II | Pelabresib + Ruxolitinib Pelabresib | A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis | Completed | USA | POL | NLD | ITA | GBR | FRA | DEU | CAN | BEL | 0 |
| NCT04603495 | Phase III | Pelabresib + Ruxolitinib Ruxolitinib | Study of CPI-0610 in Myelofibrosis (MF) (MANIFEST-2) | Active, not recruiting | USA | TUR | POL | NLD | ITA | ISR | HUN | GRC | GBR | FRA | ESP | DEU | CZE | CAN | BEL | AUT | AUS | 5 |
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