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Therapy Name	R547
Synonyms
Therapy Description	R547 is a small molecule that selectively inhibits cyclin-dependent kinases, leading to cell cycle arrest and apoptosis in cancer cells (PMID: 17121911, PMID: 32123493).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
R547		R-547\|R 547\|RO 4584820\|RO4584820	CDK1 Inhibitor 13 CDK2 Inhibitor 31 CDK4 Inhibitor 17	R547 is a small molecule that selectively inhibits cyclin-dependent kinases, leading to cell cycle arrest and apoptosis in cancer cells (PMID: 17121911, PMID: 32123493).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
RB1 mut TP53 mut	prostate carcinoma	sensitive	R547	Preclinical - Cell line xenograft	Actionable	In a preclinical study, R547 inhibited proliferation of prostate carcinoma cell lines harboring Tp53 and Rb1 mutations in culture and reduced tumor growth in xenograft models (PMID: 17121911).	17121911
RB1 wild-type TP53 mut	breast carcinoma	sensitive	R547	Preclinical - Cell line xenograft	Actionable	In a preclinical study, R547 inhibited proliferation of breast carcinoma cell lines harboring mutant Tp53 and wild-type Rb1 in culture and reduced tumor growth in xenograft models (PMID: 17121911).	17121911
RB1 wild-type TP53 wild-type	lung carcinoma	sensitive	R547	Preclinical - Cell line xenograft	Actionable	In a preclinical study, R547 inhibited proliferation of lung carcinoma cell lines harboring wild-type Tp53 and Rb1 in culture and reduced tumor growth in xenograft models (PMID: 17121911).	17121911
RB1 wild-type TP53 wild-type	colon carcinoma	sensitive	R547	Preclinical - Cell line xenograft	Actionable	In a preclinical study, R547 inhibited proliferation of colon carcinoma cell lines harboring wild-type Tp53 and Rb1 in culture and reduced tumor growth in xenograft models (PMID: 17121911).	17121911
RB1 wild-type TP53 wild-type	melanoma	sensitive	R547	Preclinical - Cell line xenograft	Actionable	In a preclinical study, R547 inhibited proliferation of melanoma cell lines harboring wild-type Tp53 and Rb1 in culture and reduced tumor growth in xenograft models (PMID: 17121911).	17121911
RB1 mut TP53 mut	breast carcinoma	sensitive	R547	Preclinical	Actionable	In a preclinical study, R547 inhibited proliferation of breast carcinoma cell lines harboring TP53 and RB1 mutations in culture (PMID: 17121911).	17121911
RB1 mut TP53 mut	cervical cancer	sensitive	R547	Preclinical	Actionable	In a preclinical study, R547 inhibited proliferation of cervical carcinoma cell lines harboring Tp53 and Rb1 mutations (PMID: 17121911).	17121911
RB1 wild-type TP53 mut	colon carcinoma	sensitive	R547	Preclinical	Actionable	In a preclinical study, R547 inhibited proliferation of colon carcinoma cell lines harboring mutant Tp53 and wild-type Rb1 (PMID: 17121911).	17121911
RB1 wild-type TP53 mut	mantle cell lymphoma	sensitive	R547	Preclinical	Actionable	In a preclinical study, R547 inhibited proliferation of mantle cell lymphoma cell lines harboring mutant Tp53 and wild-type Rb1 (PMID: 17121911).	17121911
RB1 wild-type TP53 mut	osteosarcoma	sensitive	R547	Preclinical	Actionable	In a preclinical study, R547 inhibited proliferation of osteosarcoma cell lines harboring mutant Tp53 and wild-type Rb1 (PMID: 17121911).	17121911
RB1 wild-type TP53 wild-type	breast carcinoma	sensitive	R547	Preclinical	Actionable	In a preclinical study, R547 inhibited proliferation of breast carcinoma cell lines harboring wild-type Tp53 and Rb1 (PMID: 17121911).	17121911
RB1 wild-type TP53 wild-type	mantle cell lymphoma	sensitive	R547	Preclinical	Actionable	In a preclinical study, R547 inhibited proliferation of mantle cell lymphoma cell lines harboring wild-type Tp53 and Rb1 (PMID: 17121911).	17121911

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