Therapy Detail

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Therapy Name Cobolimab + Dostarlimab-gxly
Synonyms
Therapy Description

TSR-042 is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (Eur J Cancer 2016 Dec; 69 (Suppl 1):S102, Abstract # 310).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cobolimab TSR-022 Immune Checkpoint Inhibitor 149 TIM-3 Antibody 9 Cobolimab (TSR-022) is a monoclonal antibody that targets T-cell immunoglobulin and mucin domain-3 protein (TIM-3, HAVCR2), potentially resulting in enhanced anti-tumor immune response (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 2504).
Dostarlimab-gxly Jemperli TSR-042 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 Jemperli (dostarlimab-gxly) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 34313545). Jemperli (dostarlimab-gxly) is FDA approved for use in patients with recurrent or advanced endometrial cancer or solid tumors harboring mismatch repair deficient (dMMR), as determined by an FDA-approved test, who have progressed on prior treatments, and in combination with Paraplatin (carboplatin) and Taxol (paclitaxel), followed by Jemperli (dostarlimab-gxly) monotherapy, in patients with primary advanced or recurrent endometrial cancer (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06238635 Phase II Cobolimab + Dostarlimab-gxly Cobolimab Dostarlimab and Cobolimab in Advanced Cervical Cancer Recruiting USA 0
NCT03680508 Phase II Cobolimab + Dostarlimab-gxly TSR-022 (Anti-TIM-3 Antibody) and TSR-042 (Anti-PD-1 Antibody) in Patients With Liver Cancer Active, not recruiting USA 0
NCT04139902 Phase II Cobolimab + Dostarlimab-gxly Dostarlimab-gxly PD-1 Inhibitor Dostarlimab (TSR-042) vs. Combination of Tim-3 Inhibitor TSR-022 and PD-1 Inhibitor Dostarlimab (TSR-042) Recruiting USA 0
NCT06521567 Phase Ib/II Cobolimab + Dostarlimab-gxly A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer Not yet recruiting USA | ITA | FRA | ESP | DNK | DEU | CZE | BRA | ARG 1
NCT02817633 Phase I Cobolimab Cobolimab + Dostarlimab-gxly + TSR-033 Cisplatin + Cobolimab + Dostarlimab-gxly + Pemetrexed Disodium Cobolimab + Dostarlimab-gxly Cobolimab + Nivolumab Cobolimab + Docetaxel Cobolimab + Docetaxel + Dostarlimab-gxly A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER) Recruiting USA | ESP 2


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