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Therapy Name Cobolimab + Dostarlimab-gxly + TSR-033
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cobolimab TSR-022 Immune Checkpoint Inhibitor 149 TIM-3 Antibody 9 Cobolimab (TSR-022) is a monoclonal antibody that targets T-cell immunoglobulin and mucin domain-3 protein (TIM-3, HAVCR2), potentially resulting in enhanced anti-tumor immune response (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 2504).
Dostarlimab-gxly Jemperli TSR-042 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 Jemperli (dostarlimab-gxly) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 34313545). Jemperli (dostarlimab-gxly) is FDA approved for use in patients with recurrent or advanced endometrial cancer or solid tumors harboring mismatch repair deficient (dMMR), as determined by an FDA-approved test, who have progressed on prior treatments, and in combination with Paraplatin (carboplatin) and Taxol (paclitaxel), followed by Jemperli (dostarlimab-gxly) monotherapy, in patients with primary advanced or recurrent endometrial cancer (FDA.gov).
TSR-033 TSR033|TSR 033 LAG3 Antibody 18 TSR-033 is a humanized monoclonal antibody that targets LAG3 and inhibits binding of class II MHC molecules, potentially resulting in enhanced anti-tumor immune response, particularly in combination with other agents (PMID: 30587557).

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  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02817633 Phase I Cobolimab Cobolimab + Dostarlimab-gxly + TSR-033 Cisplatin + Cobolimab + Dostarlimab-gxly + Pemetrexed Disodium Cobolimab + Dostarlimab-gxly Cobolimab + Nivolumab Cobolimab + Docetaxel Cobolimab + Docetaxel + Dostarlimab-gxly A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER) Recruiting USA | ESP 2


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