Therapy Detail
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| Therapy Name | Carfilzomib + Dexamethasone |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carfilzomib | Kyprolis | PR-171 | Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (PMID: 26893241). Kyprolis (carfilzomib) in combination with lenalidomide and dexamethasone, or in combination with Darzalex Faspro (Daratumumab and hyaluronidase-fihj) and dexamethasone is FDA-approved for use in patients with multiple myeloma (FDA.gov). | |
| Dexamethasone | Adexone | Desametasone |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03871829 | Phase II | Carfilzomib + Daratumumab + Dexamethasone Carfilzomib + Dexamethasone | Daratumumab Retreatment in Participants With Multiple Myeloma Who Have Been Previously Treated With Daratumumab | Terminated | USA | POL | NLD | ITA | GRC | FRA | ESP | DNK | DEU | CAN | BRA | BEL | 1 |
| NCT05552976 | Phase III | Carfilzomib + Dexamethasone Carfilzomib + CC-92480 + Dexamethasone | A Study to Evaluate CC-92480 in Combination With Carfilzomib and Dexamethasone (480Kd) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2) (SUCCESSOR-2) | Recruiting | USA | ROU | NOR | NLD | ITA | ISR | HUN | GRC | GBR | ESP | DNK | DEU | CAN | BRA | BGR | AUT | AUS | ARG | 9 |
| NCT06158841 | Phase III | Dexamethasone + Elotuzumab + Pomalidomide Carfilzomib + Dexamethasone Bortezomib + Dexamethasone + Selinexor ABBV-383 | Study Assessing Activity of Intravenous (IV) ABBV-383 Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma | Recruiting | USA | SWE | POL | ITA | ISR | HUN | GRC | FRA | ESP | DNK | DEU | BEL | AUT | AUS | 6 |
| NCT06152575 | Phase III | Dexamethasone + Elotuzumab + Pomalidomide Carfilzomib + Dexamethasone Bortezomib + Dexamethasone + Pomalidomide Elranatamab-bcmm | MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide) | Recruiting | USA | SWE | NOR | NLD | ITA | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CZE | CAN | BRA | BEL | ARG | 1 |
| NCT06413498 | Phase III | Cyclophosphamide + Fludarabine Carfilzomib + Daratumumab + Dexamethasone Daratumumab + Dexamethasone + Pomalidomide Bortezomib + Dexamethasone + Pomalidomide CART-ddBCMA Carfilzomib + Dexamethasone | A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma (iMMagine-3) | Recruiting | USA | 0 |
| NCT03275285 | Phase III | Carfilzomib + Dexamethasone + Isatuximab Carfilzomib + Dexamethasone | Multinational Clinical Study Comparing Isatuximab, Carfilzomib And Dexamethasone To Carfilzomib And Dexamethasone In Relapse And/Or Refractory Multiple Myeloma Patients (IKEMA) | Active, not recruiting | USA | TUR | NZL | ITA | HUN | GRC | GBR | FRA | ESP | CZE | CAN | BRA | AUS | 3 |
| NCT05572515 | Phase III | Teclistamab Carfilzomib + Dexamethasone Bortezomib + Dexamethasone + Pomalidomide | A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (MajesTEC-9) | Recruiting | USA | TUR | SWE | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BRA | BEL | AUT | AUS | 5 |
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