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| Therapy Name | ABBV-383 |
| Synonyms | |
| Therapy Description |
ABBV-383 (TNB-383B) is a bispecific antibody that targets alpha CD3 and BCMA, potentially resulting in the activation of T-cells and tumor cell lysis (Journal of Clinical Oncology 2018 36:15_suppl, 8034-8034, PMID: 36029527). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ABBV-383 | TNB-383B|TNB383B|TNB 383B|ABBV383|ABBV 383 | CD3 Antibody 99 TNFRSF17 Antibody 20 | ABBV-383 (TNB-383B) is a bispecific antibody that targets alpha CD3 and BCMA, potentially resulting in the activation of T-cells and tumor cell lysis (Journal of Clinical Oncology 2018 36:15_suppl, 8034-8034, PMID: 36029527). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04453397 | Expanded access | ABBV-383 | Expanded Access for TNB-383B in a Subject With Relapsed/Refractory Multiple Myeloma | No longer available | USA | 0 |
| NCT06223516 | Phase I | ABBV-383 | Study of ABBV-383 Assessing Adverse Events and Clinical Activity With Subcutaneous (SC) Injection in Adult Participants With Relapsed or Refractory Multiple Myeloma | Recruiting | USA | ISR | DEU | 1 |
| NCT05650632 | Phase I | ABBV-383 | A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma | Recruiting | USA | ISR | GBR | FRA | ESP | DNK | CAN | 0 |
| NCT06158841 | Phase III | Dexamethasone + Elotuzumab + Pomalidomide Carfilzomib + Dexamethasone Bortezomib + Dexamethasone + Selinexor ABBV-383 | Study Assessing Activity of Intravenous (IV) ABBV-383 Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma | Recruiting | USA | SWE | POL | ITA | ISR | HUN | GRC | FRA | ESP | DNK | DEU | BEL | AUT | AUS | 6 |
| NCT03933735 | Phase I | ABBV-383 | A Study of TNB-383B in Subjects With Relapsed or Refractory Multiple Myeloma | Active, not recruiting | USA | DEU | 0 |
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