Therapy Detail
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| Therapy Name | Carfilzomib + Dexamethasone + Etentamig |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carfilzomib | Kyprolis | PR-171 | Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (PMID: 26893241). Kyprolis (carfilzomib) in combination with lenalidomide and dexamethasone, or in combination with Darzalex Faspro (Daratumumab and hyaluronidase-fihj) and dexamethasone is FDA-approved for use in patients with multiple myeloma (FDA.gov). | |
| Dexamethasone | Adexone | Desametasone | ||
| Etentamig | TNB-383B|TNB383B|TNB 383B|ABBV383|ABBV 383|ABBV-383 | CD3 Antibody 119 TNFRSF17 Antibody 22 | Etentamig (ABBV-383) is a bispecific antibody that targets alpha CD3 and BCMA, potentially resulting in the activation of T-cells and tumor cell lysis (Journal of Clinical Oncology 2018 36:15_suppl, 8034-8034, PMID: 36029527). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06892522 | Phase Ib/II | Daratumumab + Dexamethasone + Lenalidomide Etentamig + Lenalidomide Carfilzomib + Daratumumab + Dexamethasone + Etentamig Carfilzomib + Dexamethasone + Etentamig Etentamig Lenalidomide Daratumumab + Etentamig + Lenalidomide | A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion Alone or in Combination With Oral, IV, Subcutaneous Daratumumab; Lenalidomide; Dexamethasone; Carfilzomib | Recruiting | USA | ISR | AUS | 1 |
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