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Drug Name MEDI5752
Trade Name
Synonyms MEDI-5752|MEDI 5752|volrustomig
Drug Descriptions

MEDI5752 is a bispecific human IgG1 monoclonal antibody that binds PD1 (PDCD1) and CTLA4, potentially resulting in enhanced anti-tumor immune response (Cancer Res 2018;78(13 Suppl):Abstract nr 2776).

DrugClasses CTLA4 Antibody 31 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121
CAS Registry Number NA
NCIT ID C171937

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Axitinib + MEDI5752 Axitinib MEDI5752 0 1
Bevacizumab + MEDI5752 Bevacizumab MEDI5752 0 1
Capecitabine + Fluorouracil + MEDI5752 + Trastuzumab deruxtecan Capecitabine Fluorouracil MEDI5752 Trastuzumab deruxtecan 0 1
Capecitabine + MEDI5752 + Oxaliplatin Capecitabine MEDI5752 Oxaliplatin 0 1
Carboplatin + Datopotamab deruxtecan + MEDI5752 Carboplatin Datopotamab deruxtecan MEDI5752 0 1
Carboplatin + MEDI5752 + Paclitaxel Carboplatin MEDI5752 Paclitaxel 0 1
Carboplatin + MEDI5752 + Paclitaxel + Pemetrexed Disodium Carboplatin MEDI5752 Paclitaxel Pemetrexed Disodium 0 0
Carboplatin + MEDI5752 + Pemetrexed Disodium Carboplatin MEDI5752 Pemetrexed Disodium 0 4
Carboplatin + MEDI5752 + Trastuzumab deruxtecan Carboplatin MEDI5752 Trastuzumab deruxtecan 0 1
Datopotamab deruxtecan + MEDI5752 Datopotamab deruxtecan MEDI5752 0 1
Fluorouracil + Leucovorin + MEDI5752 + Oxaliplatin Fluorouracil Leucovorin MEDI5752 Oxaliplatin 0 1
Lenvatinib + MEDI5752 Lenvatinib MEDI5752 0 1
MEDI5752 MEDI5752 0 7
MEDI5752 + Monalizumab MEDI5752 Monalizumab 0 1
MEDI5752 + Trastuzumab deruxtecan MEDI5752 Trastuzumab deruxtecan 0 1


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