pulmonary neuroendocrine tumor
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ID DOID:5410
Name pulmonary neuroendocrine tumor
Definition
Source DiseaseOntology.org
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SNOMEDCT_US_2023_03_01:707594002
Path disease disease of cellular proliferation cancer organ system cancer respiratory system cancer lung cancer pulmonary neuroendocrine tumor

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
EML4 - ALK Alectinib pulmonary neuroendocrine tumor predicted - sensitive detail...
RET over exp Selpercatinib pulmonary neuroendocrine tumor predicted - sensitive detail...
RET over exp Pralsetinib pulmonary neuroendocrine tumor predicted - sensitive detail...
EML4 - ALK ALK I1171N Alectinib pulmonary neuroendocrine tumor predicted - resistant detail...
EML4 - ALK ALK I1171N Ceritinib pulmonary neuroendocrine tumor predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02834013 Phase II Ipilimumab + Nivolumab Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Active, not recruiting USA 1
NCT02875223 Phase I CC-90011 A Safety and Efficacy Study of CC-90011 in Subjects With Relapsed and/or Refractory Solid Tumors and Non-Hodgkin's Lymphomas Terminated ITA | GBR | FRA | ESP 1
NCT02936323 Phase Ib/II PEN-221 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Completed USA | GBR 0
NCT03095274 Phase II Durvalumab Tremelimumab Durvalumab (MEDI4736) Plus Tremelimumab for Advanced Neuroendocrine Neoplasms of Gastroenteropancreatic or Lung Origin (DUNE) Completed ESP 0
NCT03278379 Phase II Avelumab Avelumab in G2-3 NET (NET-002) Completed CAN 0
NCT03278405 Phase Ib/II Avelumab Avelumab in G3 NEC (NET-001) Completed CAN 0
NCT03325816 Phase Ib/II Nivolumab Nivolumab and 177Lu-DOTA0-Tyr3-Octreotate for Patients With Extensive-Stage Small Cell Lung Cancer Completed USA 0
NCT03411915 Phase I XmAb18087 A Study of XmAb18087 in Subjects With NET and GIST Completed USA 0
NCT03420521 Phase II Ipilimumab + Nivolumab Nivolumab With Ipilimumab in Subjects With Neuroendocrine Tumors Terminated USA 0
NCT03670030 Phase II Nab-rapamycin A Study to Test the Effectiveness of ABI-009 in Patients With Metastatic, Unresectable, Low or Intermediate Grade Neuroendocrine Tumors of the Lung or Gastroenteropancreatic System Terminated USA 0
NCT03870399 Phase II Tamoxifen Study of Tamoxifen in Well Differentiated Neuroendocrine Tumors and Hormone Receptor Positive Expression (HORMONET) Completed USA | BRA 0
NCT03879694 Phase I Octreotide + Sargramostim + SurVaxM Survivin Long Peptide Vaccine in Treating Patients With Metastatic Neuroendocrine Tumors Completed USA 0
NCT04010357 Phase II Abemaciclib Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive SCLC Active, not recruiting USA 0
NCT04400474 Phase II Atezolizumab + Cabozantinib Trial of Cabozantinib Plus Atezolizumab in Advanced and Progressive Neoplasms of the Endocrine System. The CABATEN Study (CABATEN) Completed ESP 0
NCT04427787 Phase II Cabozantinib + Lanreotide acetate A Trial Aiming to Assess the Safety and Activity of the Combination of Cabozantinib Plus Lanreotide in GEP and NET (LOLA) Unknown status ITA 0
NCT04525638 Phase II Lutetium Lu 177 dotatate + Nivolumab A Clinical Study to Assess the Combination of Two Drugs (177Lu-DOTATATE and Nivolumab) in Neuroendocrine Tumours Unknown status ESP 0
NCT04538378 Phase II Durvalumab + Olaparib Olaparib (LYNPARZA) Plus Durvalumab (IMFINZI) in EGFR-Mutated Adenocarcinomas That Transform to Small Cell Lung Cancer (SCLC) and Other Neuroendocrine Tumors Terminated USA 0
NCT04665739 Phase II Everolimus Lutetium Lu 177 dotatate Testing Lutetium Lu 177 Dotatate in Patients With Somatostatin Receptor Positive Advanced Bronchial Neuroendocrine Tumors Recruiting USA 0
NCT04730999 Phase II Atezolizumab + Bevacizumab + Carboplatin + Etoposide Efficacy and Safety Study of a New Therapeutic Strategy in the Treatment of Extended-Disease Small-Cell Lung Cancer (CeLEBrATE) Completed ITA 0
NCT04893785 Phase II Cabozantinib + Temozolomide A Phase II Single Arm Interventional Trial Evaluating the Activity and Safety of Combination Between Cabozantinib and Temozolomide in Lung and GEP-NENS Progressive After Everolimus, Sunitinib or PRRT (CABOTEM) (CABOTEM) Recruiting ITA 0
NCT05557708 Phase I 212Pb-Pentixather A Safety Study of 212Pb-Pentixather Radioligand Therapy Not yet recruiting USA 0
NCT05746208 Phase II Lenvatinib + Pembrolizumab Lenvatinib Plus Pembrolizumab in Well Differentiated G3 Neuroendocrine Tumors Recruiting USA 0
NCT05918302 Phase III 177Lu-edotreotide Everolimus Efficacy and Safety of Radiotherapy Compared to Everolimus in Somatostatin Receptor Positive Neuroendocrine Tumors of the Lung and Thymus. (LEVEL) Recruiting ITA | FRA | ESP | BEL 0
NCT05997056 Phase II Nab-rapamycin Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR Inhibitors Recruiting USA 0
NCT06202066 Phase II Montanide ISA 51 + Sargramostim + SurVaxM + Temozolomide Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas Recruiting USA 0
NCT06472388 Phase II Everolimus Everolimus 5 mg vs 10 mg/Daily for Patients With Neuroendocrine Tumors (EVENET) Recruiting BRA 0
NCT06790706 Phase II AB154 + Zimberelimab AB154 + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers (IMMUNORARE5) Recruiting FRA 0
NCT07070232 Phase Ib/II BNT327 + YL202 YL202 Itraconazole + YL202 A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors Recruiting USA | ITA | GBR | ESP | DEU | BEL | AUS 0